Detailed information of TA system TA181150

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4564719..4565977
• Replicon: chromosome
• Accession: NZ_CP064392
• Organism: Pseudomonas aeruginosa strain SRRSH15

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9I4U4
• Locus tag: ITG70_RS21130
• Protein ID: WP_003112528.1
• Coordinates: 4564719..4565474 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: ITG70_RS21135
• Protein ID: WP_003086329.1
• Coordinates: 4565609..4565977 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ITG70_RS21120 (ITG70_21125)	4559892..4562435	+	2544	WP_003112526.1	acyl-homoserine-lactone acylase QuiP	-
ITG70_RS21125 (ITG70_21130)	4562590..4563951	-	1362	WP_010895536.1	DNA recombination protein RmuC	-
ITG70_RS21130 (ITG70_21135)	4564719..4565474	-	756	WP_003112528.1	RES family NAD+ phosphorylase	Toxin
ITG70_RS21135 (ITG70_21140)	4565609..4565977	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
ITG70_RS21140 (ITG70_21145)	4566050..4567336	-	1287	WP_003112529.1	FAD-binding oxidoreductase	-
ITG70_RS21145 (ITG70_21150)	4567392..4568981	-	1590	WP_003123191.1	aldehyde dehydrogenase family protein	-
ITG70_RS21150 (ITG70_21155)	4569060..4569536	+	477	WP_003112531.1	hypothetical protein	-
ITG70_RS21155 (ITG70_21160)	4569539..4569814	-	276	WP_010793902.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28278.42 Da
• Isoelectric Point: 7.7294

>T181150 WP_003112528.1 NZ_CP064392:c4565474-4564719 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T181150 NZ_CP085807:910610-911011 [Salmonella enterica subsp. enterica serovar Typhi]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCCTTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGACAG
GACTGGACGCTCTTGCGTCCTCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
AG

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT181150 WP_003086329.1 NZ_CP064392:c4565977-4565609 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT181150 NZ_CP085807:910363-910629 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: Q9I4U4

Antitoxin

• AlphaFold DB: V6AJU7