Detailed information of TA system TA181149

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3584943..3586164
• Replicon: chromosome
• Accession: NZ_CP064392
• Organism: Pseudomonas aeruginosa strain SRRSH15

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0C7CS07
• Locus tag: ITG70_RS16505
• Protein ID: WP_003102740.1
• Coordinates: 3585586..3586164 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: ITG70_RS16500
• Protein ID: WP_003088112.1
• Coordinates: 3584943..3585497 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ITG70_RS16475 (ITG70_16475)	3580511..3581062	+	552	WP_004343115.1	XRE family transcriptional regulator	-
ITG70_RS16480 (ITG70_16480)	3581059..3581457	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
ITG70_RS16485 (ITG70_16485)	3581470..3581793	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
ITG70_RS16490 (ITG70_16490)	3582124..3582585	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
ITG70_RS16495 (ITG70_16495)	3582590..3584785	+	2196	WP_010794059.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
ITG70_RS16500 (ITG70_16500)	3584943..3585497	+	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
ITG70_RS16505 (ITG70_16505)	3585586..3586164	+	579	WP_003102740.1	HD domain-containing protein	Toxin
ITG70_RS16510 (ITG70_16510)	3586273..3587460	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
ITG70_RS16515 (ITG70_16515)	3587450..3589621	-	2172	WP_003114950.1	type I secretion system permease/ATPase	-
ITG70_RS16520 (ITG70_16520)	3589611..3590888	-	1278	WP_003102743.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21869.70 Da
• Isoelectric Point: 5.3655

>T181149 WP_003102740.1 NZ_CP064392:3585586-3586164 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T181149 NZ_CP085807:308048-308533 [Salmonella enterica subsp. enterica serovar Typhi]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGGGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGACGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT181149 WP_003088112.1 NZ_CP064392:3584943-3585497 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT181149 NZ_CP085807:307773-308060 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAGTCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCGGGCTGCCGAGAATGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Toxin

• AlphaFold DB: A0A0C7CS07