Detailed information of TA system TA181144

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 5368196..5368701
• Replicon: chromosome
• Accession: NZ_CP064391
• Organism: Pseudomonas aeruginosa strain PartH-Paeruginosa-RM8376

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: IUJ43_RS24655
• Protein ID: WP_003083773.1
• Coordinates: 5368196..5368477 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q9I707
• Locus tag: IUJ43_RS24660
• Protein ID: WP_003112628.1
• Coordinates: 5368474..5368701 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IUJ43_RS24630 (IUJ43_24570)	5363447..5364796	+	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-
IUJ43_RS24635 (IUJ43_24575)	5364845..5365531	+	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
IUJ43_RS24640 (IUJ43_24580)	5365632..5366366	+	735	WP_003115036.1	GntR family transcriptional regulator	-
IUJ43_RS24645 (IUJ43_24585)	5366546..5366956	+	411	WP_003101225.1	aegerolysin family protein	-
IUJ43_RS24650 (IUJ43_24590)	5366988..5367896	-	909	WP_003083769.1	LysR family transcriptional regulator	-
IUJ43_RS24655 (IUJ43_24595)	5368196..5368477	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
IUJ43_RS24660 (IUJ43_24600)	5368474..5368701	-	228	WP_003112628.1	CopG family ribbon-helix-helix protein	Antitoxin
IUJ43_RS24665 (IUJ43_24605)	5368877..5369497	-	621	WP_003101226.1	hypothetical protein	-
IUJ43_RS24670 (IUJ43_24610)	5369598..5370098	+	501	WP_003112629.1	LEA type 2 family protein	-
IUJ43_RS24675 (IUJ43_24615)	5370171..5370512	+	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
IUJ43_RS24680 (IUJ43_24620)	5370594..5372021	-	1428	WP_003083784.1	GABA permease	-
IUJ43_RS24685 (IUJ43_24625)	5372190..5373683	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T181144 WP_003083773.1 NZ_CP064391:c5368477-5368196 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T181144 NZ_CP085806:c4051139-4050864 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8568.64 Da
• Isoelectric Point: 5.5740

>AT181144 WP_003112628.1 NZ_CP064391:c5368701-5368474 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT181144 NZ_CP085806:c4051402-4051142 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCACGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• PDB: 6XRW
• AlphaFold DB: Q9I707