Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2415142..2416363 Replicon chromosome
Accession NZ_CP064391
Organism Pseudomonas aeruginosa strain PartH-Paeruginosa-RM8376

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IUJ43_RS10930 Protein ID WP_003114949.1
Coordinates 2415785..2416363 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IUJ43_RS10925 Protein ID WP_003088112.1
Coordinates 2415142..2415696 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ43_RS10900 (IUJ43_10885) 2410710..2411261 + 552 WP_003102727.1 XRE family transcriptional regulator -
IUJ43_RS10905 (IUJ43_10890) 2411258..2411656 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
IUJ43_RS10910 (IUJ43_10895) 2411669..2411992 - 324 WP_003102734.1 multidrug efflux SMR transporter -
IUJ43_RS10915 (IUJ43_10900) 2412323..2412784 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
IUJ43_RS10920 (IUJ43_10905) 2412789..2414984 + 2196 WP_003114948.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
IUJ43_RS10925 (IUJ43_10910) 2415142..2415696 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
IUJ43_RS10930 (IUJ43_10915) 2415785..2416363 + 579 WP_003114949.1 HD domain-containing protein Toxin
IUJ43_RS10935 (IUJ43_10920) 2416471..2417658 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
IUJ43_RS10940 (IUJ43_10925) 2417648..2419819 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
IUJ43_RS10945 (IUJ43_10930) 2419809..2421086 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T181140 WP_003114949.1 NZ_CP064391:2415785-2416363 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T181140 NZ_CP085806:1932313-1932468 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT181140 WP_003088112.1 NZ_CP064391:2415142-2415696 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT181140 NZ_CP085806:c1932301-1932243 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References