Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) TscAT/-
Location 2492702..2493237 Replicon chromosome
Accession NZ_CP064389
Organism Staphylococcus aureus strain PartE-Saureus-RM8376

Toxin (Protein)


Gene name TscT Uniprot ID A0A4P7P340
Locus tag IUJ40_RS12695 Protein ID WP_001103945.1
Coordinates 2492702..2493025 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag IUJ40_RS12700 Protein ID WP_001058486.1
Coordinates 2493028..2493237 (-) Length 70 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ40_RS12665 (2487804) 2487804..2488145 - 342 WP_001190614.1 hypothetical protein -
IUJ40_RS12670 (2488707) 2488707..2489348 - 642 WP_140045510.1 pathogenicity island protein -
IUJ40_RS12675 (2489345) 2489345..2489629 - 285 WP_000998179.1 hypothetical protein -
IUJ40_RS12680 (2489631) 2489631..2489993 - 363 WP_031765322.1 hypothetical protein -
IUJ40_RS12685 (2490294) 2490294..2491751 - 1458 WP_031765320.1 virulence-associated E family protein -
IUJ40_RS12690 (2491768) 2491768..2492637 - 870 WP_031765319.1 primase alpha helix C-terminal domain-containing protein -
IUJ40_RS12695 (2492702) 2492702..2493025 - 324 WP_001103945.1 DUF1474 family protein Toxin
IUJ40_RS12700 (2493028) 2493028..2493237 - 210 WP_001058486.1 hypothetical protein Antitoxin
IUJ40_RS12705 (2493230) 2493230..2493376 - 147 WP_000784875.1 hypothetical protein -
IUJ40_RS12710 (2493388) 2493388..2493660 - 273 WP_001138300.1 helix-turn-helix domain-containing protein -
IUJ40_RS12715 (2493661) 2493661..2493873 - 213 WP_001245562.1 helix-turn-helix transcriptional regulator -
IUJ40_RS12720 (2494045) 2494045..2494770 + 726 WP_000668215.1 helix-turn-helix transcriptional regulator -
IUJ40_RS12725 (2495034) 2495034..2496248 + 1215 WP_140045509.1 site-specific integrase -
IUJ40_RS12730 (2496361) 2496361..2497080 + 720 WP_000400841.1 type II toxin-antitoxin system PemK/MazF family toxin -
IUJ40_RS12735 (2497312) 2497312..2497554 - 243 WP_000897044.1 30S ribosomal protein S18 -
IUJ40_RS12740 (2497606) 2497606..2498109 - 504 WP_000934799.1 single-stranded DNA-binding protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2477252..2498861 21609


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-90)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 108 a.a.        Molecular weight: 12665.26 Da        Isoelectric Point: 4.7124

>T181134 WP_001103945.1 NZ_CP064389:c2493025-2492702 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFDELIQKF
HEIEKASSDVSLATESDDAKNSIKVAE

Download         Length: 324 bp

>T181134 NZ_CP085806:303667-303951 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGCAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8252.31 Da        Isoelectric Point: 4.3718

>AT181134 WP_001058486.1 NZ_CP064389:c2493237-2493028 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT181134 NZ_CP085806:303435-303677 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A4P7P340


Antitoxin

Source ID Structure

References