Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2006621..2007098 Replicon chromosome
Accession NZ_CP064389
Organism Staphylococcus aureus strain PartE-Saureus-RM8376

Toxin (Protein)


Gene name TsaT Uniprot ID A0A0H3K6W0
Locus tag IUJ40_RS10220 Protein ID WP_000052077.1
Coordinates 2006910..2007098 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IUJ40_RS10215 Protein ID WP_001059690.1
Coordinates 2006621..2006881 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ40_RS10185 (2002406) 2002406..2003578 - 1173 WP_000195429.1 IS256-like element IS256 family transposase -
IUJ40_RS10190 (2003699) 2003699..2004193 + 495 WP_000569886.1 GNAT family N-acetyltransferase -
IUJ40_RS10195 (2004348) 2004348..2004965 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
IUJ40_RS10200 (2005038) 2005038..2005619 - 582 WP_001140693.1 histidine phosphatase family protein -
IUJ40_RS10205 (2005844) 2005844..2006080 + 237 WP_000368687.1 hypothetical protein -
IUJ40_RS10210 (2006077) 2006077..2006280 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
IUJ40_RS10215 (2006621) 2006621..2006881 + 261 WP_001059690.1 hypothetical protein Antitoxin
IUJ40_RS10220 (2006910) 2006910..2007098 + 189 WP_000052077.1 hypothetical protein Toxin
IUJ40_RS10225 (2007286) 2007286..2007855 + 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
IUJ40_RS10230 (2007943) 2007943..2008227 + 285 WP_001004395.1 hypothetical protein -
IUJ40_RS10235 (2008289) 2008289..2008507 + 219 WP_000005886.1 hypothetical protein -
IUJ40_RS10240 (2009003) 2009003..2009203 - 201 WP_001059082.1 cold-shock protein -
IUJ40_RS10245 (2009560) 2009560..2010246 - 687 WP_001548082.1 thermonuclease family protein -
IUJ40_RS10250 (2010587) 2010587..2011057 - 471 WP_033841859.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2002406..2003578 1172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7186.87 Da        Isoelectric Point: 9.9971

>T181133 WP_000052077.1 NZ_CP064389:2006910-2007098 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTIILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T181133 NZ_CP085806:196564-197055 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT181133 WP_001059690.1 NZ_CP064389:2006621-2006881 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT181133 NZ_CP085806:196274-196567 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCTGCCCGTGCTGCCGCCGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3K6W0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References