Detailed information of TA system TA181132

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_19(antitoxin)
• Location: 1762345..1763136
• Replicon: chromosome
• Accession: NZ_CP064389
• Organism: Staphylococcus aureus strain PartE-Saureus-RM8376

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: IUJ40_RS08980
• Protein ID: WP_023487066.1
• Coordinates: 1762672..1763136 (+)
• Length: 155 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E7YIA0
• Locus tag: IUJ40_RS08975
• Protein ID: WP_000333630.1
• Coordinates: 1762345..1762659 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IUJ40_RS08915 (1757639)	1757639..1757860	-	222	WP_000815403.1	DUF2483 family protein	-
IUJ40_RS08920 (1757870)	1757870..1758130	-	261	WP_000291076.1	DUF1108 family protein	-
IUJ40_RS08925 (1758224)	1758224..1758385	-	162	WP_000066026.1	DUF1270 family protein	-
IUJ40_RS08930 (1758378)	1758378..1758515	-	138	WP_000230552.1	hypothetical protein	-
IUJ40_RS08935 (1758565)	1758565..1758795	+	231	WP_000395455.1	hypothetical protein	-
IUJ40_RS08940 (1758962)	1758962..1759714	-	753	WP_023487064.1	phage antirepressor KilAC domain-containing protein	-
IUJ40_RS08945 (1759716)	1759716..1759901	-	186	WP_000933363.1	helix-turn-helix transcriptional regulator	-
IUJ40_RS08950 (1760341)	1760341..1760550	+	210	WP_000642492.1	hypothetical protein	-
IUJ40_RS08955 (1760540)	1760540..1760683	-	144	WP_000939498.1	hypothetical protein	-
IUJ40_RS08960 (1760698)	1760698..1761141	-	444	WP_023487065.1	hypothetical protein	-
IUJ40_RS08965 (1761167)	1761167..1761943	-	777	WP_001148544.1	Rha family transcriptional regulator	-
IUJ40_RS08970 (1761957)	1761957..1762193	-	237	WP_001121027.1	helix-turn-helix transcriptional regulator	-
IUJ40_RS08975 (1762345)	1762345..1762659	+	315	WP_000333630.1	helix-turn-helix transcriptional regulator	Antitoxin
IUJ40_RS08980 (1762672)	1762672..1763136	+	465	WP_023487066.1	toxin-antitoxin system toxin component	Toxin
IUJ40_RS08985 (1763168)	1763168..1763848	+	681	WP_000392109.1	type II toxin-antitoxin system PemK/MazF family toxin	-
IUJ40_RS08990 (1764055)	1764055..1765440	+	1386	WP_023487067.1	recombinase family protein	-
IUJ40_RS08995 (1765557)	1765557..1765730	-	174	WP_000290472.1	50S ribosomal protein L32	-
IUJ40_RS09000 (1765810)	1765810..1766367	-	558	WP_000872158.1	DUF177 domain-containing protein	-
IUJ40_RS09005 (1766494)	1766494..1767633	+	1140	WP_000843611.1	nucleotidyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1721430..1765440	44010

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (4-62)

Sequences

Toxin

Protein

• Length: 155 a.a.
• Molecular weight: 18140.52 Da
• Isoelectric Point: 4.7927

>T181132 WP_023487066.1 NZ_CP064389:1762672-1763136 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEFSITFEPLRVFKLHHID

Nucleotide

• Length: 465 bp

>T181132 NZ_CP085805:c4522519-4522028 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12063.56 Da
• Isoelectric Point: 6.4736

>AT181132 WP_000333630.1 NZ_CP064389:1762345-1762659 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Nucleotide

• Length: 315 bp

>AT181132 NZ_CP085805:c4522809-4522516 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCTGCCCGTGCTGCCGCCGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E7YIA0