Detailed information of TA system TA181131

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 877965..878741
• Replicon: chromosome
• Accession: NZ_CP064389
• Organism: Staphylococcus aureus strain PartE-Saureus-RM8376

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: IUJ40_RS04640
• Protein ID: WP_000031108.1
• Coordinates: 878589..878741 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: IUJ40_RS04635
• Protein ID: WP_001251224.1
• Coordinates: 877965..878564 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IUJ40_RS04615 (873881)	873881..875338	+	1458	WP_000649907.1	ABC transporter permease subunit	-
IUJ40_RS04620 (875331)	875331..876053	+	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
IUJ40_RS04625 (876204)	876204..877331	+	1128	Protein_882	tRNA epoxyqueuosine(34) reductase QueG	-
IUJ40_RS04630 (877336)	877336..877806	+	471	WP_000181398.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
IUJ40_RS04635 (877965)	877965..878564	+	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
IUJ40_RS04640 (878589)	878589..878741	+	153	WP_000031108.1	SAS053 family protein	Toxin
IUJ40_RS04645 (878806)	878806..879282	-	477	WP_023487198.1	hypothetical protein	-
IUJ40_RS04650 (879401)	879401..879796	+	396	WP_000901021.1	hypothetical protein	-
IUJ40_RS04655 (879992)	879992..881377	+	1386	WP_000116224.1	class II fumarate hydratase	-
IUJ40_RS04660 (881840)	881840..882661	-	822	WP_000669376.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T181131 WP_000031108.1 NZ_CP064389:878589-878741 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T181131 NZ_CP085805:c4415416-4415132 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGCAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT181131 WP_001251224.1 NZ_CP064389:877965-878564 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT181131 NZ_CP085805:c4415648-4415406 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4