Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 672431..672960 Replicon chromosome
Accession NZ_CP064389
Organism Staphylococcus aureus strain PartE-Saureus-RM8376

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag IUJ40_RS03360 Protein ID WP_000621175.1
Coordinates 672598..672960 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag IUJ40_RS03355 Protein ID WP_000948331.1
Coordinates 672431..672601 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ40_RS03325 (667467) 667467..668027 + 561 WP_001092411.1 K(+)-transporting ATPase subunit C -
IUJ40_RS03330 (668236) 668236..668715 + 480 WP_001287088.1 hypothetical protein -
IUJ40_RS03335 (668708) 668708..670291 + 1584 WP_001294626.1 PH domain-containing protein -
IUJ40_RS03340 (670278) 670278..670769 + 492 WP_001205910.1 PH domain-containing protein -
IUJ40_RS03345 (670773) 670773..671132 + 360 WP_000581200.1 holo-ACP synthase -
IUJ40_RS03350 (671198) 671198..672346 + 1149 WP_001281145.1 alanine racemase -
IUJ40_RS03355 (672431) 672431..672601 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
IUJ40_RS03360 (672598) 672598..672960 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IUJ40_RS03365 (673310) 673310..674311 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
IUJ40_RS03370 (674431) 674431..674757 + 327 WP_001052491.1 anti-sigma factor antagonist -
IUJ40_RS03375 (674759) 674759..675238 + 480 WP_001190829.1 anti-sigma B factor RsbW -
IUJ40_RS03380 (675213) 675213..675983 + 771 WP_001041103.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T181126 WP_000621175.1 NZ_CP064389:672598-672960 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T181126 NZ_CP085805:c3036238-3036135 [Salmonella enterica subsp. enterica serovar Enteritidis]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT181126 WP_000948331.1 NZ_CP064389:672431-672601 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT181126 NZ_CP085805:3036133-3036278 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References