Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3116899..3117700 Replicon chromosome
Accession NZ_CP064387
Organism Escherichia coli O104:H4 strain PartB-EcoliO104H4-RM8376

Toxin (Protein)


Gene name yeeV Uniprot ID D3GUT5
Locus tag IUJ37_RS15560 Protein ID WP_001094430.1
Coordinates 3117323..3117700 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID D3GUT4
Locus tag IUJ37_RS15555 Protein ID WP_001285620.1
Coordinates 3116899..3117276 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ37_RS15525 (3112102) 3112102..3113610 - 1509 WP_001189118.1 group II intron reverse transcriptase/maturase -
IUJ37_RS15530 (3114283) 3114283..3115022 - 740 Protein_3046 IS3 family transposase -
IUJ37_RS15535 (3115079) 3115079..3115204 + 126 Protein_3047 DUF945 domain-containing protein -
IUJ37_RS15540 (3115546) 3115546..3116019 + 474 WP_000855057.1 antirestriction protein -
IUJ37_RS15545 (3116035) 3116035..3116511 + 477 WP_001387238.1 RadC family protein -
IUJ37_RS15550 (3116598) 3116598..3116819 + 222 WP_000692350.1 DUF987 domain-containing protein -
IUJ37_RS15555 (3116899) 3116899..3117276 + 378 WP_001285620.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
IUJ37_RS15560 (3117323) 3117323..3117700 + 378 WP_001094430.1 TA system toxin CbtA family protein Toxin
IUJ37_RS15565 (3117697) 3117697..3118185 + 489 WP_000761715.1 DUF5983 family protein -
IUJ37_RS15570 (3118205) 3118205..3118402 + 198 WP_000772029.1 DUF957 domain-containing protein -
IUJ37_RS15575 (3118487) 3118487..3119329 + 843 WP_001290187.1 DUF4942 domain-containing protein -
IUJ37_RS15580 (3120078) 3120078..3121616 + 1539 WP_001187182.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13971.82 Da        Isoelectric Point: 6.8608

>T181104 WP_001094430.1 NZ_CP064387:3117323-3117700 [Escherichia coli O104:H4]
MNTLPDTHVREASGCPSPITIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T181104 NZ_CP085804:462296-462580 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGCAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13698.52 Da        Isoelectric Point: 5.9505

>AT181104 WP_001285620.1 NZ_CP064387:3116899-3117276 [Escherichia coli O104:H4]
VSDTLPGTTPPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDVDAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPATTV

Download         Length: 378 bp

>AT181104 NZ_CP085804:462064-462306 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y6M7

Antitoxin

Source ID Structure
PDB 2INW
AlphaFold DB A0A0E0Y522

References