Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1484537..1485355 Replicon chromosome
Accession NZ_CP064387
Organism Escherichia coli O104:H4 strain PartB-EcoliO104H4-RM8376

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0E0Y102
Locus tag IUJ37_RS07630 Protein ID WP_000771609.1
Coordinates 1484537..1484911 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0E0Y470
Locus tag IUJ37_RS07635 Protein ID WP_001285568.1
Coordinates 1485002..1485355 (-) Length 118 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ37_RS07590 (1479541) 1479541..1480032 - 492 WP_001297187.1 DUF1097 domain-containing protein -
IUJ37_RS07595 (1480134) 1480134..1480688 - 555 WP_001001902.1 molecular chaperone YcdY -
IUJ37_RS07600 (1480712) 1480712..1481449 - 738 WP_000283664.1 zinc-binding phosphatase -
IUJ37_RS07605 (1481504) 1481504..1482442 - 939 WP_000351313.1 glyoxylate/hydroxypyruvate reductase GhrA -
IUJ37_RS07615 (1482913) 1482913..1483755 - 843 WP_001274560.1 DUF4942 domain-containing protein -
IUJ37_RS07620 (1483840) 1483840..1484037 - 198 WP_000839270.1 DUF957 domain-containing protein -
IUJ37_RS07625 (1484049) 1484049..1484540 - 492 WP_000976860.1 DUF5983 family protein -
IUJ37_RS07630 (1484537) 1484537..1484911 - 375 WP_000771609.1 TA system toxin CbtA family protein Toxin
IUJ37_RS07635 (1485002) 1485002..1485355 - 354 WP_001285568.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
IUJ37_RS07640 (1485431) 1485431..1485652 - 222 WP_000692357.1 DUF987 domain-containing protein -
IUJ37_RS07645 (1485715) 1485715..1486191 - 477 WP_001186756.1 RadC family protein -
IUJ37_RS07650 (1486207) 1486207..1486680 - 474 WP_000855049.1 antirestriction protein -
IUJ37_RS07655 (1486774) 1486774..1487019 - 246 WP_001164966.1 hypothetical protein -
IUJ37_RS07660 (1487019) 1487019..1487840 - 822 WP_001241709.1 DUF932 domain-containing protein -
IUJ37_RS07665 (1488088) 1488088..1489701 - 1614 WP_000080172.1 IS66-like element ISEc43 family transposase -
IUJ37_RS07670 (1489732) 1489732..1490082 - 351 WP_000624688.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14006.09 Da        Isoelectric Point: 7.2652

>T181099 WP_000771609.1 NZ_CP064387:c1484911-1484537 [Escherichia coli O104:H4]
MKLLPDTHVREASCCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T181099 NZ_CP085803:c4350472-4350104 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA

Antitoxin


Download         Length: 118 a.a.        Molecular weight: 13064.82 Da        Isoelectric Point: 5.9541

>AT181099 WP_001285568.1 NZ_CP064387:c1485355-1485002 [Escherichia coli O104:H4]
VSDTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSGELNPR
HQHTVTLYAKGLTCDADTLGSCGYVYLAVYPTPETKK

Download         Length: 354 bp

>AT181099 NZ_CP085803:c4350690-4350469 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y102

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y470

References