Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 1390207..1390688 | Replicon | chromosome |
| Accession | NZ_CP064387 | ||
| Organism | Escherichia coli O104:H4 strain PartB-EcoliO104H4-RM8376 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7YS45 |
| Locus tag | IUJ37_RS07115 | Protein ID | WP_014966210.1 |
| Coordinates | 1390398..1390688 (+) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | A0A0D7Y007 |
| Locus tag | IUJ37_RS07110 | Protein ID | WP_000100896.1 |
| Coordinates | 1390207..1390398 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IUJ37_RS07065 (1385359) | 1385359..1385537 | - | 179 | Protein_1389 | hypothetical protein | - |
| IUJ37_RS07070 (1385539) | 1385539..1386288 | - | 750 | WP_001289900.1 | ead/Ea22-like family protein | - |
| IUJ37_RS07075 (1386285) | 1386285..1386971 | - | 687 | WP_000034251.1 | ead/Ea22-like family protein | - |
| IUJ37_RS07080 (1386958) | 1386958..1387452 | - | 495 | WP_001275731.1 | class I SAM-dependent methyltransferase | - |
| IUJ37_RS07085 (1387449) | 1387449..1387871 | - | 423 | WP_000416574.1 | DUF977 family protein | - |
| IUJ37_RS07090 (1387912) | 1387912..1388874 | - | 963 | WP_000095671.1 | helix-turn-helix domain-containing protein | - |
| IUJ37_RS07095 (1388897) | 1388897..1389322 | - | 426 | WP_000693845.1 | toxin YdaT family protein | - |
| IUJ37_RS07100 (1389306) | 1389306..1389581 | - | 276 | WP_001048458.1 | helix-turn-helix transcriptional regulator | - |
| IUJ37_RS07105 (1389689) | 1389689..1390189 | + | 501 | WP_000824162.1 | helix-turn-helix transcriptional regulator | - |
| IUJ37_RS07110 (1390207) | 1390207..1390398 | + | 192 | WP_000100896.1 | hypothetical protein | Antitoxin |
| IUJ37_RS07115 (1390398) | 1390398..1390688 | + | 291 | WP_014966210.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| IUJ37_RS07120 (1390958) | 1390958..1391110 | + | 153 | WP_000379548.1 | DUF1391 family protein | - |
| IUJ37_RS07125 (1391122) | 1391122..1391460 | + | 339 | WP_000394541.1 | hypothetical protein | - |
| IUJ37_RS07130 (1391449) | 1391449..1391643 | - | 195 | WP_001295058.1 | hypothetical protein | - |
| IUJ37_RS07135 (1392210) | 1392210..1392398 | + | 189 | WP_000449175.1 | cell division inhibition protein DicB | - |
| IUJ37_RS07140 (1392395) | 1392395..1392583 | + | 189 | WP_000199475.1 | DUF1482 family protein | - |
| IUJ37_RS07145 (1392676) | 1392676..1395114 | + | 2439 | WP_000102130.1 | exonuclease | - |
| IUJ37_RS07150 (1395176) | 1395176..1395445 | + | 270 | WP_000003742.1 | excisionase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1343376..1403701 | 60325 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11176.05 Da Isoelectric Point: 9.9854
>T181098 WP_014966210.1 NZ_CP064387:1390398-1390688 [Escherichia coli O104:H4]
MLPILWLPSARDDLRQIVAYIAKENPPAARRLKIRIETSVLSLTEHPYLYPPSERVPSLREIVTHPNYIILYRVTASNIE
IVNVVHSRRQYPNKTC
MLPILWLPSARDDLRQIVAYIAKENPPAARRLKIRIETSVLSLTEHPYLYPPSERVPSLREIVTHPNYIILYRVTASNIE
IVNVVHSRRQYPNKTC
Download Length: 291 bp
>T181098 NZ_CP085803:c4302053-4301778 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7033.83 Da Isoelectric Point: 4.0270
>AT181098 WP_000100896.1 NZ_CP064387:1390207-1390398 [Escherichia coli O104:H4]
MSTALSPIISEFETVEQENSYNEWLRTKVAASLSDPRPAIPHDEVMAEMENLIAQLAATNRSE
MSTALSPIISEFETVEQENSYNEWLRTKVAASLSDPRPAIPHDEVMAEMENLIAQLAATNRSE
Download Length: 192 bp
>AT181098 NZ_CP085803:c4302316-4302056 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCACGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCACGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0D7YS45 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0D7Y007 |