Detailed information of TA system TA181087

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 42949..43574
• Replicon: plasmid unnamed
• Accession: NZ_CP064386
• Organism: Salmonella enterica subsp. enterica strain PartC-Senterica-RM8376

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: IUJ38_RS23805
• Protein ID: WP_000911322.1
• Coordinates: 43176..43574 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: IUJ38_RS23800
• Protein ID: WP_000450265.1
• Coordinates: 42949..43176 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IUJ38_RS23800 (IUJ38_23700)	42949..43176	+	228	WP_000450265.1	toxin-antitoxin system antitoxin VapB	Antitoxin
IUJ38_RS23805 (IUJ38_23705)	43176..43574	+	399	WP_000911322.1	type II toxin-antitoxin system VapC family toxin	Toxin
IUJ38_RS23810 (IUJ38_23710)	43583..45826	-	2244	WP_000009320.1	type IV conjugative transfer system coupling protein TraD	-
IUJ38_RS23815 (IUJ38_23715)	46203..46934	-	732	WP_000782438.1	conjugal transfer complement resistance protein TraT	-
IUJ38_RS23820 (IUJ38_23720)	46970..47464	-	495	WP_010999946.1	entry exclusion protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	spvB / spvC / fdeC / pefB / pefA / pefC / pefD / rck	1..93933	93933

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-125)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14887.13 Da
• Isoelectric Point: 8.5264

>T181087 WP_000911322.1 NZ_CP064386:43176-43574 [Salmonella enterica subsp. enterica]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLDVLDYDTPAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVGGLRTEDWS

Nucleotide

• Length: 399 bp

>T181087 NZ_CP085803:449603-450094 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8509.49 Da
• Isoelectric Point: 4.5358

>AT181087 WP_000450265.1 NZ_CP064386:42949-43176 [Salmonella enterica subsp. enterica]
METSVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGESWDEWFDGNNVSADFMDNREQPSVQERESF

Nucleotide

• Length: 228 bp

>AT181087 NZ_CP085803:449313-449606 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCTGCCCGTGCTGCCGCCGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA