Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 15589..16114 | Replicon | plasmid unnamed |
| Accession | NZ_CP064386 | ||
| Organism | Salmonella enterica subsp. enterica strain PartC-Senterica-RM8376 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | I3W3D5 |
| Locus tag | IUJ38_RS23645 | Protein ID | WP_001159863.1 |
| Coordinates | 15589..15894 (-) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | M7S5D0 |
| Locus tag | IUJ38_RS23650 | Protein ID | WP_000813641.1 |
| Coordinates | 15896..16114 (-) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IUJ38_RS23605 (IUJ38_23510) | 10968..11528 | - | 561 | WP_000900095.1 | inverse autotransporter beta domain-containing protein | - |
| IUJ38_RS23610 (IUJ38_23515) | 11684..11971 | + | 288 | WP_071530243.1 | hypothetical protein | - |
| IUJ38_RS23615 (IUJ38_23520) | 12248..12733 | - | 486 | WP_000905606.1 | membrane protein | - |
| IUJ38_RS23620 (IUJ38_23525) | 12727..13215 | - | 489 | WP_001075507.1 | CaiF/GrlA family transcriptional regulator | - |
| IUJ38_RS23625 (IUJ38_23530) | 13402..13953 | - | 552 | WP_000545754.1 | EAL domain-containing protein | - |
| IUJ38_RS23630 (IUJ38_23535) | 13962..14744 | - | 783 | WP_000082169.1 | site-specific integrase | - |
| IUJ38_RS23635 (IUJ38_23540) | 14779..15300 | - | 522 | WP_000198608.1 | hypothetical protein | - |
| IUJ38_RS23640 (IUJ38_23545) | 15297..15587 | - | 291 | WP_001266176.1 | hypothetical protein | - |
| IUJ38_RS23645 (IUJ38_23550) | 15589..15894 | - | 306 | WP_001159863.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| IUJ38_RS23650 (IUJ38_23555) | 15896..16114 | - | 219 | WP_000813641.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| IUJ38_RS23655 (IUJ38_23560) | 16790..17311 | + | 522 | WP_010999942.1 | hypothetical protein | - |
| IUJ38_RS23660 | 17355..17783 | - | 429 | Protein_23 | hypothetical protein | - |
| IUJ38_RS23665 (IUJ38_23565) | 17795..18091 | + | 297 | WP_001687482.1 | hypothetical protein | - |
| IUJ38_RS23670 (IUJ38_23570) | 18585..19574 | + | 990 | WP_001527061.1 | RepB family plasmid replication initiator protein | - |
| IUJ38_RS23675 (IUJ38_23575) | 19833..20277 | - | 445 | Protein_26 | tyrosine-type recombinase/integrase | - |
| IUJ38_RS23680 (IUJ38_23580) | 20446..20827 | - | 382 | Protein_27 | YgiW/YdeI family stress tolerance OB fold protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | spvB / spvC / fdeC / pefB / pefA / pefC / pefD / rck | 1..93933 | 93933 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11587.48 Da Isoelectric Point: 6.9787
>T181086 WP_001159863.1 NZ_CP064386:c15894-15589 [Salmonella enterica subsp. enterica]
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
Download Length: 306 bp
>T181086 NZ_CP085803:140259-140570 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG
Antitoxin
Download Length: 73 a.a. Molecular weight: 8314.16 Da Isoelectric Point: 4.5203
>AT181086 WP_000813641.1 NZ_CP064386:c16114-15896 [Salmonella enterica subsp. enterica]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW
Download Length: 219 bp
>AT181086 NZ_CP085803:140571-140861 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | I3W3D5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A656ICA6 |