Detailed information of TA system TA181085

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 4131205..4131825
• Replicon: chromosome
• Accession: NZ_CP064385
• Organism: Salmonella enterica subsp. enterica strain PartC-Senterica-RM8376

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: IUJ38_RS19895
• Protein ID: WP_001280991.1
• Coordinates: 4131205..4131423 (-)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: IUJ38_RS19900
• Protein ID: WP_000344807.1
• Coordinates: 4131451..4131825 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IUJ38_RS19855 (4126429)	4126429..4126998	+	570	WP_000779803.1	YbaY family lipoprotein	-
IUJ38_RS19860 (4127031)	4127031..4127420	-	390	WP_000961285.1	MGMT family protein	-
IUJ38_RS19870 (4127651)	4127651..4129201	-	1551	WP_000213139.1	EAL domain-containing protein	-
IUJ38_RS19875 (4129426)	4129426..4129686	+	261	WP_000801415.1	type B 50S ribosomal protein L31	-
IUJ38_RS19880 (4129692)	4129692..4129832	+	141	WP_001197749.1	type B 50S ribosomal protein L36	-
IUJ38_RS19885 (4129888)	4129888..4130358	-	471	WP_000136181.1	YlaC family protein	-
IUJ38_RS19890 (4130475)	4130475..4131026	-	552	WP_001278792.1	maltose O-acetyltransferase	-
IUJ38_RS19895 (4131205)	4131205..4131423	-	219	WP_001280991.1	HHA domain-containing protein	Toxin
IUJ38_RS19900 (4131451)	4131451..4131825	-	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
IUJ38_RS19905 (4132321)	4132321..4135470	-	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
IUJ38_RS19910 (4135493)	4135493..4136686	-	1194	WP_001039202.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T181085 WP_001280991.1 NZ_CP064385:c4131423-4131205 [Salmonella enterica subsp. enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T181085 NZ_CP085803:c139026-138715 [Salmonella enterica subsp. enterica serovar Enteritidis]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACACTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATGATCGGGGTAATAAAGAATGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT181085 WP_000344807.1 NZ_CP064385:c4131825-4131451 [Salmonella enterica subsp. enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT181085 NZ_CP085803:c138718-138272 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0