Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3437086..3437602 Replicon chromosome
Accession NZ_CP064385
Organism Salmonella enterica subsp. enterica strain PartC-Senterica-RM8376

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag IUJ38_RS16740 Protein ID WP_000220578.1
Coordinates 3437318..3437602 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag IUJ38_RS16735 Protein ID WP_000212724.1
Coordinates 3437086..3437328 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ38_RS16715 (3432106) 3432106..3433239 + 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -
IUJ38_RS16720 (3433223) 3433223..3434341 + 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
IUJ38_RS16725 (3434338) 3434338..3435078 + 741 WP_000779263.1 KDGP aldolase family protein -
IUJ38_RS16730 (3435095) 3435095..3437008 + 1914 WP_001212137.1 BglG family transcription antiterminator -
IUJ38_RS16735 (3437086) 3437086..3437328 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IUJ38_RS16740 (3437318) 3437318..3437602 + 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IUJ38_RS16745 (3437606) 3437606..3438070 - 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
IUJ38_RS16750 (3438191) 3438191..3440329 - 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
IUJ38_RS16755 (3440738) 3440738..3442390 - 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T181080 WP_000220578.1 NZ_CP064385:3437318-3437602 [Salmonella enterica subsp. enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T181080 NZ_CP064385:3437318-3437602 [Salmonella enterica subsp. enterica]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT181080 WP_000212724.1 NZ_CP064385:3437086-3437328 [Salmonella enterica subsp. enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT181080 NZ_CP064385:3437086-3437328 [Salmonella enterica subsp. enterica]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References