Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2583369..2584129 Replicon chromosome
Accession NZ_CP064385
Organism Salmonella enterica subsp. enterica strain PartC-Senterica-RM8376

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag IUJ38_RS12715 Protein ID WP_000533909.1
Coordinates 2583369..2583854 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag IUJ38_RS12720 Protein ID WP_000965886.1
Coordinates 2583842..2584129 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ38_RS12685 (2578439) 2578439..2579101 + 663 WP_000747548.1 OmpA family lipoprotein -
IUJ38_RS12690 (2579320) 2579320..2580294 + 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
IUJ38_RS12695 (2580344) 2580344..2581054 - 711 WP_000190524.1 DUF3053 domain-containing protein -
IUJ38_RS12700 (2581493) 2581493..2581783 + 291 WP_000455790.1 HTH-type transcriptional regulator -
IUJ38_RS12705 (2582072) 2582072..2582284 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
IUJ38_RS12710 (2582458) 2582458..2582997 + 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
IUJ38_RS12715 (2583369) 2583369..2583854 - 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
IUJ38_RS12720 (2583842) 2583842..2584129 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
IUJ38_RS12725 (2584307) 2584307..2584774 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
IUJ38_RS12730 (2584946) 2584946..2585221 - 276 Protein_2496 IS3 family transposase -
IUJ38_RS12735 (2585403) 2585403..2587472 - 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
IUJ38_RS12740 (2587482) 2587482..2588393 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
IUJ38_RS12745 (2588532) 2588532..2588834 - 303 WP_000605590.1 YsaB family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T181076 WP_000533909.1 NZ_CP064385:c2583854-2583369 [Salmonella enterica subsp. enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T181076 NZ_CP085802:c3555578-3555291 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT181076 WP_000965886.1 NZ_CP064385:c2584129-2583842 [Salmonella enterica subsp. enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT181076 NZ_CP085802:c3555304-3555002 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAGCATGGTTAAACATAAACGCGGCAATGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References