Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1951635..1952295 Replicon chromosome
Accession NZ_CP064385
Organism Salmonella enterica subsp. enterica strain PartC-Senterica-RM8376

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag IUJ38_RS09650 Protein ID WP_000244756.1
Coordinates 1951635..1952048 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag IUJ38_RS09655 Protein ID WP_000351186.1
Coordinates 1952029..1952295 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ38_RS09630 (1947576) 1947576..1949309 - 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -
IUJ38_RS09635 (1949315) 1949315..1950028 - 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IUJ38_RS09640 (1950052) 1950052..1950948 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
IUJ38_RS09645 (1951061) 1951061..1951582 + 522 WP_001055885.1 flavodoxin FldB -
IUJ38_RS09650 (1951635) 1951635..1952048 - 414 WP_000244756.1 protein YgfX Toxin
IUJ38_RS09655 (1952029) 1952029..1952295 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
IUJ38_RS09660 (1952545) 1952545..1953525 + 981 WP_000874172.1 tRNA-modifying protein YgfZ -
IUJ38_RS09665 (1953641) 1953641..1954300 - 660 WP_000250289.1 hemolysin III family protein -
IUJ38_RS09670 (1954464) 1954464..1954775 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
IUJ38_RS09675 (1954934) 1954934..1956367 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T181073 WP_000244756.1 NZ_CP064385:c1952048-1951635 [Salmonella enterica subsp. enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T181073 NZ_CP085802:c2261368-2261265 [Salmonella enterica subsp. enterica serovar Enteritidis]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT181073 WP_000351186.1 NZ_CP064385:c1952295-1952029 [Salmonella enterica subsp. enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT181073 NZ_CP085802:2261263-2261408 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References