Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RHH(antitoxin) |
| Location | 79374..79933 | Replicon | plasmid unnamed |
| Accession | NZ_CP064384 | ||
| Organism | Escherichia coli O157:H7 strain PartA-EcoliO157H7-RM8376 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | O82928 |
| Locus tag | IUJ36_RS28150 | Protein ID | WP_000421248.1 |
| Coordinates | 79658..79933 (+) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | C1J8K5 |
| Locus tag | IUJ36_RS28145 | Protein ID | WP_001178089.1 |
| Coordinates | 79374..79658 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IUJ36_RS28105 (74565) | 74565..75125 | + | 561 | WP_000840472.1 | fertility inhibition protein FinO | - |
| IUJ36_RS28110 (75258) | 75258..75470 | + | 213 | WP_001302189.1 | ANR family transcriptional regulator | - |
| IUJ36_RS28115 (75715) | 75715..76176 | + | 462 | WP_001233853.1 | thermonuclease family protein | - |
| IUJ36_RS28120 (76222) | 76222..76431 | + | 210 | WP_001302200.1 | hemolysin expression modulator Hha | - |
| IUJ36_RS28125 (76469) | 76469..76807 | + | 339 | WP_000766796.1 | hypothetical protein | - |
| IUJ36_RS28130 (77047) | 77047..77301 | + | 255 | WP_000083831.1 | replication regulatory protein RepA | - |
| IUJ36_RS28135 (77537) | 77537..77611 | + | 75 | WP_001370046.1 | RepA leader peptide Tap | - |
| IUJ36_RS28140 (77604) | 77604..78461 | + | 858 | WP_000130945.1 | incFII family plasmid replication initiator RepA | - |
| IUJ36_RS28145 (79374) | 79374..79658 | + | 285 | WP_001178089.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| IUJ36_RS28150 (79658) | 79658..79933 | + | 276 | WP_000421248.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| IUJ36_RS28155 (80028) | 80028..80234 | + | 207 | WP_001105064.1 | hypothetical protein | - |
| IUJ36_RS28160 (80334) | 80334..80549 | - | 216 | Protein_88 | transposase | - |
| IUJ36_RS28165 (80593) | 80593..81159 | - | 567 | Protein_89 | IS3-like element IS600 family transposase | - |
| IUJ36_RS28170 (81159) | 81159..81575 | - | 417 | Protein_90 | IS91 family transposase | - |
| IUJ36_RS28175 (81575) | 81575..81760 | - | 186 | WP_001302179.1 | hypothetical protein | - |
| IUJ36_RS28180 (81937) | 81937..84147 | + | 2211 | WP_000592771.1 | catalase/peroxidase KatP | - |
| IUJ36_RS28185 (84191) | 84191..84580 | + | 390 | WP_001172748.1 | cytochrome b562 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | stcE / exeE / exeG / hlyC / hlyA / hlyB / hlyD / toxB / espP | 1..92060 | 92060 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10735.42 Da Isoelectric Point: 9.9324
>T181061 WP_000421248.1 NZ_CP064384:79658-79933 [Escherichia coli O157:H7]
MELKWSSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR
MELKWSSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR
Download Length: 276 bp
>T181061 NZ_CP085801:c3599707-3599399 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10474.89 Da Isoelectric Point: 5.6558
>AT181061 WP_001178089.1 NZ_CP064384:79374-79658 [Escherichia coli O157:H7]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR
Download Length: 285 bp
>AT181061 NZ_CP085801:c3599949-3599710 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2Z6FAZ0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A731IHA8 |