Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4952097..4952692 Replicon chromosome
Accession NZ_CP064383
Organism Escherichia coli O157:H7 strain PartA-EcoliO157H7-RM8376

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag IUJ36_RS24970 Protein ID WP_000239579.1
Coordinates 4952342..4952692 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID Q8XCF3
Locus tag IUJ36_RS24965 Protein ID WP_001223210.1
Coordinates 4952097..4952348 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ36_RS24955 (4947762) 4947762..4951541 + 3780 WP_000060930.1 autotransporter assembly complex protein TamB -
IUJ36_RS24960 (4951544) 4951544..4951885 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
IUJ36_RS24965 (4952097) 4952097..4952348 + 252 WP_001223210.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
IUJ36_RS24970 (4952342) 4952342..4952692 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
IUJ36_RS24975 (4952772) 4952772..4953302 - 531 WP_000055075.1 inorganic diphosphatase -
IUJ36_RS24980 (4953612) 4953612..4954568 + 957 WP_000265942.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
IUJ36_RS24985 (4954708) 4954708..4956210 + 1503 WP_000205806.1 sugar ABC transporter ATP-binding protein -
IUJ36_RS24990 (4956224) 4956224..4957246 + 1023 WP_001301928.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T181057 WP_000239579.1 NZ_CP064383:4952342-4952692 [Escherichia coli O157:H7]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T181057 NZ_CP085801:c2261507-2261404 [Salmonella enterica subsp. enterica serovar Enteritidis]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9299.64 Da        Isoelectric Point: 4.4201

>AT181057 WP_001223210.1 NZ_CP064383:4952097-4952348 [Escherichia coli O157:H7]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEVQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT181057 NZ_CP085801:2261402-2261547 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure

References