Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4046380..4047011 Replicon chromosome
Accession NZ_CP064383
Organism Escherichia coli O157:H7 strain PartA-EcoliO157H7-RM8376

Toxin (Protein)


Gene name hicA Uniprot ID Q8X5S6
Locus tag IUJ36_RS20750 Protein ID WP_001259386.1
Coordinates 4046736..4047011 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag IUJ36_RS20745 Protein ID WP_000593555.1
Coordinates 4046380..4046739 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ36_RS20715 (4041492) 4041492..4041965 + 474 WP_001161553.1 PTS sugar transporter subunit IIA -
IUJ36_RS20720 (4041962) 4041962..4042243 + 282 WP_000084025.1 PTS sugar transporter subunit IIB -
IUJ36_RS20725 (4042320) 4042320..4043678 + 1359 WP_001302220.1 PTS galactitol transporter subunit IIC -
IUJ36_RS20730 (4043671) 4043671..4045179 + 1509 WP_001301773.1 FGGY-family carbohydrate kinase -
IUJ36_RS20735 (4045169) 4045169..4045438 + 270 WP_000933060.1 HPr family phosphocarrier protein -
IUJ36_RS20740 (4045470) 4045470..4046330 + 861 WP_001131788.1 class II aldolase -
IUJ36_RS20745 (4046380) 4046380..4046739 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IUJ36_RS20750 (4046736) 4046736..4047011 - 276 WP_001259386.1 type II toxin-antitoxin system HicA family toxin Toxin
IUJ36_RS20755 (4047084) 4047084..4048208 - 1125 WP_001301659.1 ABC transporter permease -
IUJ36_RS20760 (4048208) 4048208..4050943 - 2736 WP_000149107.1 ribosome-associated ATPase/putative transporter RbbA -
IUJ36_RS20765 (4050940) 4050940..4052007 - 1068 WP_000361458.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10165.92 Da        Isoelectric Point: 10.7076

>T181053 WP_001259386.1 NZ_CP064383:c4047011-4046736 [Escherichia coli O157:H7]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKLILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T181053 NZ_CP085801:359514-359927 [Salmonella enterica subsp. enterica serovar Enteritidis]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT181053 WP_000593555.1 NZ_CP064383:c4046739-4046380 [Escherichia coli O157:H7]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT181053 NZ_CP085801:359267-359533 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I9WXY7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References