Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1679370..1680008 Replicon chromosome
Accession NZ_CP064383
Organism Escherichia coli O157:H7 strain PartA-EcoliO157H7-RM8376

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag IUJ36_RS08760 Protein ID WP_000813794.1
Coordinates 1679832..1680008 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag IUJ36_RS08755 Protein ID WP_001270286.1
Coordinates 1679370..1679786 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ36_RS08735 (1674522) 1674522..1675463 - 942 WP_001251320.1 ABC transporter permease -
IUJ36_RS08740 (1675464) 1675464..1676477 - 1014 WP_000220402.1 ABC transporter ATP-binding protein -
IUJ36_RS08745 (1676495) 1676495..1677640 - 1146 WP_000047432.1 ABC transporter substrate-binding protein -
IUJ36_RS08750 (1677885) 1677885..1679291 - 1407 WP_000760654.1 PLP-dependent aminotransferase family protein -
IUJ36_RS08755 (1679370) 1679370..1679786 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
IUJ36_RS08760 (1679832) 1679832..1680008 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
IUJ36_RS08765 (1680230) 1680230..1680460 + 231 WP_000494244.1 YncJ family protein -
IUJ36_RS08770 (1680552) 1680552..1682513 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
IUJ36_RS08775 (1682586) 1682586..1683122 - 537 WP_000429145.1 DNA-binding transcriptional regulator SutR -
IUJ36_RS08780 (1683175) 1683175..1684386 + 1212 WP_071525382.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T181037 WP_000813794.1 NZ_CP064383:c1680008-1679832 [Escherichia coli O157:H7]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T181037 NZ_CP085800:c1278451-1278296 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT181037 WP_001270286.1 NZ_CP064383:c1679786-1679370 [Escherichia coli O157:H7]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT181037 NZ_CP085800:1278463-1278521 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References