Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 582833..583538 Replicon chromosome
Accession NZ_CP064383
Organism Escherichia coli O157:H7 strain PartA-EcoliO157H7-RM8376

Toxin (Protein)


Gene name relE Uniprot ID Q8X3N0
Locus tag IUJ36_RS02695 Protein ID WP_000539519.1
Coordinates 583152..583538 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag IUJ36_RS02690 Protein ID WP_001280945.1
Coordinates 582833..583162 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ36_RS02675 (577990) 577990..578901 + 912 WP_001236044.1 glutathione ABC transporter permease GsiD -
IUJ36_RS02680 (579079) 579079..581427 + 2349 WP_000950320.1 EAL domain-containing protein -
IUJ36_RS02685 (581435) 581435..582763 + 1329 WP_000086905.1 GGDEF domain-containing protein -
IUJ36_RS02690 (582833) 582833..583162 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
IUJ36_RS02695 (583152) 583152..583538 - 387 WP_000539519.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IUJ36_RS02700 (583764) 583764..585089 - 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
IUJ36_RS02705 (585302) 585302..585685 + 384 WP_000497137.1 biofilm formation regulator BssR -
IUJ36_RS02710 (585796) 585796..586911 + 1116 WP_000554959.1 aldose sugar dehydrogenase YliI -
IUJ36_RS02715 (586908) 586908..587534 - 627 WP_001295292.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14279.42 Da        Isoelectric Point: 9.9296

>T181035 WP_000539519.1 NZ_CP064383:c583538-583152 [Escherichia coli O157:H7]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGSKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T181035 NZ_CP085799:4382788-4383186 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT181035 WP_001280945.1 NZ_CP064383:c583162-582833 [Escherichia coli O157:H7]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT181035 NZ_CP085799:4382561-4382788 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References