Detailed information of TA system TA181033

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 10608..11170
• Replicon: plasmid unnamed
• Accession: NZ_CP064380
• Organism: Vibrio furnissii strain PartQ-Vfurnissii-RM8376

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: IUJ52_RS15365
• Protein ID: WP_038152854.1
• Coordinates: 10868..11170 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: IUJ52_RS15360
• Protein ID: WP_004729600.1
• Coordinates: 10608..10853 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IUJ52_RS15335 (IUJ52_15320)	6322..7296	-	975	WP_050780295.1	recombinase RecT	-
IUJ52_RS15340 (IUJ52_15325)	7472..7939	-	468	WP_004729597.1	hypothetical protein	-
IUJ52_RS15345 (IUJ52_15330)	8190..8417	-	228	WP_038152853.1	hypothetical protein	-
IUJ52_RS15350 (IUJ52_15335)	8647..9570	+	924	WP_004729598.1	IS5 family transposase	-
IUJ52_RS15355 (IUJ52_15340)	9871..10407	-	537	Protein_13	recombinase family protein	-
IUJ52_RS15360 (IUJ52_15345)	10608..10853	+	246	WP_004729600.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IUJ52_RS15365 (IUJ52_15350)	10868..11170	+	303	WP_038152854.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IUJ52_RS15370 (IUJ52_15355)	11167..11769	-	603	WP_004729602.1	recombinase family protein	-
IUJ52_RS15375 (IUJ52_15360)	12379..13455	-	1077	WP_038152856.1	replication initiation protein	-
IUJ52_RS15380 (IUJ52_15365)	14399..15121	+	723	WP_004729604.1	hypothetical protein	-
IUJ52_RS15385 (IUJ52_15370)	15111..15860	+	750	WP_038152858.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..76098	76098
	-	flank	IS/Tn	-	-	8647..9570	923

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-56)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11644.32 Da
• Isoelectric Point: 6.7572

>T181033 WP_038152854.1 NZ_CP064380:10868-11170 [Vibrio furnissii]
MSSYKLSPLAQSDLTDIRRYTIEHWGSTQWSVYFNELQESMSLLASNELIGIQIPEMGERYYRFPLKHHVIYYITQEDHI
VIVAVLGKHMSPAKHFASIS

Nucleotide

• Length: 303 bp

>T181033 NZ_CP085799:3905569-3905844 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9115.57 Da
• Isoelectric Point: 4.5702

>AT181033 WP_004729600.1 NZ_CP064380:10608-10853 [Vibrio furnissii]
MQSLTANTAKTKFGDLLMKVQREPVQISKNGSPVAVMMSCEEYEQLEALKMMLVKSRFEQAEIDIRNGDLVDGDEFMKSL
A

Nucleotide

• Length: 246 bp

>AT181033 NZ_CP085799:3905306-3905566 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCACGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA