Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 5933124..5933678 Replicon chromosome
Accession NZ_CP064377
Organism Achromobacter xylosoxidans strain PartM-Axylosoxidans-RM8376

Toxin (Protein)


Gene name relE Uniprot ID A0A0D6FFH4
Locus tag IUJ48_RS27275 Protein ID WP_006386989.1
Coordinates 5933124..5933402 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D6FFH2
Locus tag IUJ48_RS27280 Protein ID WP_024067400.1
Coordinates 5933472..5933678 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ48_RS27250 (IUJ48_27185) 5929056..5929742 + 687 WP_006386994.1 hypothetical protein -
IUJ48_RS27255 (IUJ48_27190) 5929827..5930303 - 477 WP_006386993.1 bacterioferritin -
IUJ48_RS27260 (IUJ48_27195) 5930728..5931591 - 864 WP_227740234.1 DMT family transporter -
IUJ48_RS27265 (IUJ48_27200) 5931756..5932676 + 921 WP_006386991.1 LysR substrate-binding domain-containing protein -
IUJ48_RS27270 (IUJ48_27205) 5932646..5932945 - 300 WP_006386990.1 (2Fe-2S)-binding protein -
IUJ48_RS27275 (IUJ48_27210) 5933124..5933402 - 279 WP_006386989.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IUJ48_RS27280 (IUJ48_27215) 5933472..5933678 - 207 WP_024067400.1 hypothetical protein Antitoxin
IUJ48_RS27285 (IUJ48_27220) 5933772..5935217 - 1446 WP_024067399.1 RNA polymerase factor sigma-54 -
IUJ48_RS27290 (IUJ48_27225) 5935216..5935866 + 651 WP_024067398.1 hypothetical protein -
IUJ48_RS27295 (IUJ48_27230) 5936059..5937036 + 978 WP_024067397.1 tripartite tricarboxylate transporter substrate binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10370.91 Da        Isoelectric Point: 9.0854

>T181030 WP_006386989.1 NZ_CP064377:c5933402-5933124 [Achromobacter xylosoxidans]
MLDVSWLQTAADDLAGIISYIAERSPQAARDLRQRIDNAVLSLARHPCRYRAGRVSGTRECVVHPNYVVVYRVTALAIEV
VNIVHARREYPP

Download         Length: 279 bp

>T181030 NZ_CP085799:3357112-3357423 [Salmonella enterica subsp. enterica serovar Enteritidis]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACACTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATGATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7729.62 Da        Isoelectric Point: 4.5026

>AT181030 WP_024067400.1 NZ_CP064377:c5933678-5933472 [Achromobacter xylosoxidans]
MGPIPSSILSEFETEEQAVSYDRWFRAKVQASLDDPRPAVSHQRVMARIDAIIETACRRQLDPQDGEN

Download         Length: 207 bp

>AT181030 NZ_CP085799:3357420-3357866 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6FFH4

Antitoxin

Source ID Structure
AlphaFold DB A0A0D6FFH2

References