Detailed information of TA system TA181029

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 5012325..5012898
• Replicon: chromosome
• Accession: NZ_CP064377
• Organism: Achromobacter xylosoxidans strain PartM-Axylosoxidans-RM8376

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: IUJ48_RS23000
• Protein ID: WP_058207222.1
• Coordinates: 5012325..5012702 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: IUJ48_RS23005
• Protein ID: WP_054471260.1
• Coordinates: 5012689..5012898 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IUJ48_RS22975 (IUJ48_22925)	5008997..5009914	+	918	WP_024067857.1	septum site-determining protein MinC	-
IUJ48_RS22980 (IUJ48_22930)	5010103..5010918	+	816	WP_006388978.1	septum site-determining protein MinD	-
IUJ48_RS22985 (IUJ48_22935)	5010922..5011179	+	258	WP_006388977.1	cell division topological specificity factor MinE	-
IUJ48_RS22990 (IUJ48_22940)	5011309..5011533	-	225	WP_006388976.1	glycine zipper 2TM domain-containing protein	-
IUJ48_RS22995 (IUJ48_22945)	5011724..5012257	-	534	WP_024067855.1	isochorismatase family protein	-
IUJ48_RS23000 (IUJ48_22950)	5012325..5012702	-	378	WP_058207222.1	type II toxin-antitoxin system VapC family toxin	Toxin
IUJ48_RS23005 (IUJ48_22955)	5012689..5012898	-	210	WP_054471260.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
IUJ48_RS23010 (IUJ48_22960)	5013023..5014696	-	1674	WP_024067854.1	energy-dependent translational throttle protein EttA	-
IUJ48_RS23015 (IUJ48_22965)	5014848..5015666	+	819	WP_058207221.1	AAC(3) family N-acetyltransferase	-
IUJ48_RS23020 (IUJ48_22970)	5015679..5016605	-	927	WP_020924995.1	DMT family transporter	-
IUJ48_RS23025 (IUJ48_22975)	5016704..5017492	+	789	WP_024067852.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (2-44)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13890.17 Da
• Isoelectric Point: 6.3726

>T181029 WP_058207222.1 NZ_CP064377:c5012702-5012325 [Achromobacter xylosoxidans]
MILVDTSIWIDHLSDGEPCLVRLLEEESVLMHPFIAGELALGSLGRRDVVLGTMSLLPQVVRASHDEVMHFLHSERLFGK
GIGYVDLHLLASTRLTPGAALWTREKRLQALATTLSLAVDPPRYH

Nucleotide

• Length: 378 bp

>T181029 NZ_CP085799:c3355879-3355568 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 7521.62 Da
• Isoelectric Point: 9.9435

>AT181029 WP_054471260.1 NZ_CP064377:c5012898-5012689 [Achromobacter xylosoxidans]
VRTTVTLDDDLLELARTYTGVQETSALVTRALTQLVQKEAAKRLAKLGGSSPKLKPIPRRQTETCNDPG

Nucleotide

• Length: 210 bp

>AT181029 NZ_CP085799:c3355567-3355277 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA