Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 621091..621655 Replicon chromosome
Accession NZ_CP064377
Organism Achromobacter xylosoxidans strain PartM-Axylosoxidans-RM8376

Toxin (Protein)


Gene name relE Uniprot ID A0A0D6IHV7
Locus tag IUJ48_RS02850 Protein ID WP_020926667.1
Coordinates 621374..621655 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D6IHW1
Locus tag IUJ48_RS02845 Protein ID WP_020926666.1
Coordinates 621091..621387 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ48_RS02820 (IUJ48_02805) 616546..616857 - 312 WP_006386651.1 helix-turn-helix transcriptional regulator -
IUJ48_RS02825 (IUJ48_02810) 616854..617222 - 369 WP_006386650.1 type II toxin-antitoxin system RelE/ParE family toxin -
IUJ48_RS02830 (IUJ48_02815) 617392..618327 - 936 WP_006386649.1 protein translocase subunit SecF -
IUJ48_RS02835 (IUJ48_02820) 618379..620259 - 1881 WP_006386648.1 protein translocase subunit SecD -
IUJ48_RS02840 (IUJ48_02825) 620375..620719 - 345 WP_006386647.1 preprotein translocase subunit YajC -
IUJ48_RS02845 (IUJ48_02830) 621091..621387 + 297 WP_020926666.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IUJ48_RS02850 (IUJ48_02835) 621374..621655 + 282 WP_020926667.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IUJ48_RS02855 (IUJ48_02840) 621705..622841 - 1137 WP_024070175.1 tRNA guanosine(34) transglycosylase Tgt -
IUJ48_RS02860 (IUJ48_02845) 622838..623893 - 1056 WP_054442897.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
IUJ48_RS02865 (IUJ48_02850) 624129..624962 - 834 WP_024070173.1 IclR family transcriptional regulator -
IUJ48_RS02870 (IUJ48_02855) 625084..626097 + 1014 WP_024070172.1 LLM class flavin-dependent oxidoreductase -
IUJ48_RS02875 (IUJ48_02860) 626120..626623 + 504 WP_006386642.1 flavin reductase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-52)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10262.77 Da        Isoelectric Point: 7.0080

>T181026 WP_020926667.1 NZ_CP064377:621374-621655 [Achromobacter xylosoxidans]
VPAVEWSSAARADLLAIVDYISDDNPDAAQRLKDDIETKAAQLPARPALYRPGRIAGTREMVVRANYIIVYAADALAVRI
LRILHAAQQWPPQ

Download         Length: 282 bp

>T181026 NZ_CP085799:c2866137-2865829 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10717.24 Da        Isoelectric Point: 7.3208

>AT181026 WP_020926666.1 NZ_CP064377:621091-621387 [Achromobacter xylosoxidans]
MPQTSMLHVRVDDKLKADATEKLAEFGLTISDAVRILLTRVAKEGGLPAGLTTDAQAHDAWFRAKVQEALADTGPAVPHQ
QVMDEAQALIDRKRRARS

Download         Length: 297 bp

>AT181026 NZ_CP085799:c2866379-2866140 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6IHV7

Antitoxin

Source ID Structure
AlphaFold DB A0A0D6IHW1

References