Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4755177..4755831 Replicon chromosome
Accession NZ_CP064376
Organism Shigella sonnei strain PartP-Ssonnei-RM8376

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag IUJ51_RS24050 Protein ID WP_000244777.1
Coordinates 4755424..4755831 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag IUJ51_RS24045 Protein ID WP_000354046.1
Coordinates 4755177..4755443 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ51_RS24020 (4750346) 4750346..4751089 + 744 WP_000951938.1 SDR family oxidoreductase -
IUJ51_RS24025 (4751146) 4751146..4752579 - 1434 WP_005137189.1 6-phospho-beta-glucosidase BglA -
IUJ51_RS24030 (4752624) 4752624..4752935 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
IUJ51_RS24035 (4753099) 4753099..4753758 + 660 WP_000250274.1 hemolysin III family protein -
IUJ51_RS24040 (4753954) 4753954..4754934 - 981 WP_000886060.1 tRNA-modifying protein YgfZ -
IUJ51_RS24045 (4755177) 4755177..4755443 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
IUJ51_RS24050 (4755424) 4755424..4755831 + 408 WP_000244777.1 protein YgfX Toxin
IUJ51_RS24055 (4755871) 4755871..4756392 - 522 WP_001055874.1 flavodoxin FldB -
IUJ51_RS24060 (4756504) 4756504..4757400 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
IUJ51_RS24065 (4757425) 4757425..4758135 + 711 WP_140046308.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IUJ51_RS24070 (4758141) 4758141..4759874 + 1734 WP_000813167.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T181024 WP_000244777.1 NZ_CP064376:4755424-4755831 [Shigella sonnei]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T181024 NZ_CP085799:2436787-2437044 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCAAAACCCACATGACCACCTATTACTCACAAATCCCCAGCCT
GCATCTTAAGGGCGACTGGCTGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAGCAGCTTTATCAGGCTAAACAGGTGGTTAAGGGAATT
AAGGACGTGCTGGTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT181024 WP_000354046.1 NZ_CP064376:4755177-4755443 [Shigella sonnei]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT181024 NZ_CP085799:c2436962-2436630 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References