Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2641760..2642378 Replicon chromosome
Accession NZ_CP064376
Organism Shigella sonnei strain PartP-Ssonnei-RM8376

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag IUJ51_RS13645 Protein ID WP_001291435.1
Coordinates 2642160..2642378 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag IUJ51_RS13640 Protein ID WP_000344800.1
Coordinates 2641760..2642134 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ51_RS13630 (2636849) 2636849..2638042 + 1194 WP_011310152.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IUJ51_RS13635 (2638065) 2638065..2641214 + 3150 WP_001132464.1 efflux RND transporter permease AcrB -
IUJ51_RS13640 (2641760) 2641760..2642134 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
IUJ51_RS13645 (2642160) 2642160..2642378 + 219 WP_001291435.1 HHA domain-containing protein Toxin
IUJ51_RS13650 (2642549) 2642549..2643100 + 552 WP_000102564.1 maltose O-acetyltransferase -
IUJ51_RS13655 (2643216) 2643216..2643686 + 471 WP_000136192.1 YlaC family protein -
IUJ51_RS13660 (2643905) 2643905..2645133 + 1229 WP_088895425.1 IS3-like element IS2 family transposase -
IUJ51_RS13665 (2645186) 2645186..2646734 + 1549 Protein_2666 cyclic-guanylate-specific phosphodiesterase PdeB -
IUJ51_RS13670 (2646776) 2646776..2647129 - 354 WP_000878140.1 DUF1428 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T181019 WP_001291435.1 NZ_CP064376:2642160-2642378 [Shigella sonnei]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T181019 NZ_CP085798:4560455-4560823 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT181019 WP_000344800.1 NZ_CP064376:2641760-2642134 [Shigella sonnei]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT181019 NZ_CP085798:4560237-4560458 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References