Detailed information of TA system TA181010

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 1382916..1383400
• Replicon: chromosome
• Accession: NZ_CP064376
• Organism: Shigella sonnei strain PartP-Ssonnei-RM8376

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A377EAU1
• Locus tag: IUJ51_RS07165
• Protein ID: WP_014334020.1
• Coordinates: 1383110..1383400 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: A0A376K4R9
• Locus tag: IUJ51_RS07160
• Protein ID: WP_005142544.1
• Coordinates: 1382916..1383110 (+)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IUJ51_RS07130 (1379323)	1379323..1379688	-	366	Protein_1384	DUF1627 domain-containing protein	-
IUJ51_RS07135 (1379710)	1379710..1380456	-	747	WP_000788740.1	ATP-binding protein	-
IUJ51_RS07140 (1380463)	1380463..1381527	-	1065	WP_001262380.1	hypothetical protein	-
IUJ51_RS07145 (1381599)	1381599..1382024	-	426	WP_000693826.1	toxin YdaT family protein	-
IUJ51_RS07150 (1382021)	1382021..1382284	-	264	WP_001048456.1	helix-turn-helix transcriptional regulator	-
IUJ51_RS07155 (1382411)	1382411..1382896	+	486	WP_053002468.1	helix-turn-helix domain-containing protein	-
IUJ51_RS07160 (1382916)	1382916..1383110	+	195	WP_005142544.1	hypothetical protein	Antitoxin
IUJ51_RS07165 (1383110)	1383110..1383400	+	291	WP_014334020.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IUJ51_RS07170 (1383679)	1383679..1383831	+	153	WP_000379558.1	DUF1391 family protein	-
IUJ51_RS07175 (1383843)	1383843..1384208	+	366	WP_024174355.1	hypothetical protein	-
IUJ51_RS07185 (1385586)	1385586..1386374	+	789	WP_000935603.1	Rha family phage regulatory protein	-
IUJ51_RS07195 (1387122)	1387122..1387217	+	96	Protein_1397	transcriptional regulator	-
IUJ51_RS07200 (1387228)	1387228..1387416	+	189	WP_000449206.1	cell division inhibition protein DicB	-
IUJ51_RS07205 (1387413)	1387413..1387604	+	192	WP_001090204.1	DUF1482 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	vgrG/tssI / rhs/PAAR / rhs/PAAR / sodB	1249702..1482618	232916

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11062.93 Da
• Isoelectric Point: 10.2013

>T181010 WP_014334020.1 NZ_CP064376:1383110-1383400 [Shigella sonnei]
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS

Nucleotide

• Length: 291 bp

>T181010 NZ_CP085798:2981721-2981939 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7097.98 Da
• Isoelectric Point: 4.1759

>AT181010 WP_005142544.1 NZ_CP064376:1382916-1383110 [Shigella sonnei]
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE

Nucleotide

• Length: 195 bp

>AT181010 NZ_CP085798:2981319-2981693 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Structures

Toxin

• AlphaFold DB: A0A377EAU1

Antitoxin

• AlphaFold DB: A0A376K4R9