Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1382916..1383400 Replicon chromosome
Accession NZ_CP064376
Organism Shigella sonnei strain PartP-Ssonnei-RM8376

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A377EAU1
Locus tag IUJ51_RS07165 Protein ID WP_014334020.1
Coordinates 1383110..1383400 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID A0A376K4R9
Locus tag IUJ51_RS07160 Protein ID WP_005142544.1
Coordinates 1382916..1383110 (+) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ51_RS07130 (1379323) 1379323..1379688 - 366 Protein_1384 DUF1627 domain-containing protein -
IUJ51_RS07135 (1379710) 1379710..1380456 - 747 WP_000788740.1 ATP-binding protein -
IUJ51_RS07140 (1380463) 1380463..1381527 - 1065 WP_001262380.1 hypothetical protein -
IUJ51_RS07145 (1381599) 1381599..1382024 - 426 WP_000693826.1 toxin YdaT family protein -
IUJ51_RS07150 (1382021) 1382021..1382284 - 264 WP_001048456.1 helix-turn-helix transcriptional regulator -
IUJ51_RS07155 (1382411) 1382411..1382896 + 486 WP_053002468.1 helix-turn-helix domain-containing protein -
IUJ51_RS07160 (1382916) 1382916..1383110 + 195 WP_005142544.1 hypothetical protein Antitoxin
IUJ51_RS07165 (1383110) 1383110..1383400 + 291 WP_014334020.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IUJ51_RS07170 (1383679) 1383679..1383831 + 153 WP_000379558.1 DUF1391 family protein -
IUJ51_RS07175 (1383843) 1383843..1384208 + 366 WP_024174355.1 hypothetical protein -
IUJ51_RS07185 (1385586) 1385586..1386374 + 789 WP_000935603.1 Rha family phage regulatory protein -
IUJ51_RS07195 (1387122) 1387122..1387217 + 96 Protein_1397 transcriptional regulator -
IUJ51_RS07200 (1387228) 1387228..1387416 + 189 WP_000449206.1 cell division inhibition protein DicB -
IUJ51_RS07205 (1387413) 1387413..1387604 + 192 WP_001090204.1 DUF1482 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vgrG/tssI / rhs/PAAR / rhs/PAAR / sodB 1249702..1482618 232916


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11062.93 Da        Isoelectric Point: 10.2013

>T181010 WP_014334020.1 NZ_CP064376:1383110-1383400 [Shigella sonnei]
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS

Download         Length: 291 bp

>T181010 NZ_CP085798:2981721-2981939 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7097.98 Da        Isoelectric Point: 4.1759

>AT181010 WP_005142544.1 NZ_CP064376:1382916-1383110 [Shigella sonnei]
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE

Download         Length: 195 bp

>AT181010 NZ_CP085798:2981319-2981693 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377EAU1

Antitoxin

Source ID Structure
AlphaFold DB A0A376K4R9

References