Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 678696..679349 Replicon chromosome
Accession NZ_CP064375
Organism Acinetobacter baumannii strain PartI-Abaumannii-RM8376 isolate ATCC isolate

Toxin (Protein)


Gene name cptA Uniprot ID D0CD27
Locus tag IUJ44_RS03015 Protein ID WP_000607073.1
Coordinates 678696..679085 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag IUJ44_RS03020 Protein ID WP_001288210.1
Coordinates 679092..679349 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ44_RS03000 (IUJ44_02995) 673816..676011 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
IUJ44_RS03005 (IUJ44_03000) 676199..676765 - 567 WP_000651536.1 rhombosortase -
IUJ44_RS03010 (IUJ44_03005) 676844..677926 - 1083 WP_000049103.1 hypothetical protein -
IUJ44_RS03015 (IUJ44_03010) 678696..679085 - 390 WP_000607073.1 membrane protein Toxin
IUJ44_RS03020 (IUJ44_03015) 679092..679349 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
IUJ44_RS03025 (IUJ44_03020) 679537..680709 + 1173 WP_001190553.1 acyl-CoA dehydrogenase family protein -
IUJ44_RS03030 (IUJ44_03025) 680759..682249 - 1491 WP_000415127.1 NAD(P)/FAD-dependent oxidoreductase -
IUJ44_RS03035 (IUJ44_03030) 682431..682808 - 378 WP_001216380.1 50S ribosomal protein L17 -
IUJ44_RS03040 (IUJ44_03035) 682827..683834 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15635.91 Da        Isoelectric Point: 10.3890

>T181007 WP_000607073.1 NZ_CP064375:c679085-678696 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T181007 NZ_CP085798:c523287-522760 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT181007 WP_001288210.1 NZ_CP064375:c679349-679092 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT181007 NZ_CP085798:c523574-523284 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D0CD27

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References