181003

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 1197651..1198233 Replicon chromosome
Accession NZ_CP064374
Organism Enterococcus faecalis strain PartL-Efaecalis-RM8376

Toxin (Protein)


Gene name zeta Uniprot ID A0A0M2AE74
Locus tag IUJ47_RS05880 Protein ID WP_002355414.1
Coordinates 1197925..1198233 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag IUJ47_RS05875 Protein ID WP_002326825.1
Coordinates 1197651..1197923 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ47_RS05845 (1192932) 1192932..1193660 - 729 WP_002355404.1 GntR family transcriptional regulator -
IUJ47_RS05850 (1193837) 1193837..1194763 + 927 WP_002355406.1 hypothetical protein -
IUJ47_RS05855 (1194780) 1194780..1196063 + 1284 WP_002363033.1 PTS sugar transporter subunit IIC -
IUJ47_RS05860 (1196255) 1196255..1196377 + 123 Protein_1123 topoisomerase -
IUJ47_RS05865 (1196452) 1196452..1197348 + 897 WP_002363034.1 ParA family protein -
IUJ47_RS05870 (1197425) 1197425..1197634 + 210 WP_002363035.1 peptide-binding protein -
IUJ47_RS05875 (1197651) 1197651..1197923 + 273 WP_002326825.1 antitoxin Antitoxin
IUJ47_RS05880 (1197925) 1197925..1198233 + 309 WP_002355414.1 zeta toxin family protein Toxin
IUJ47_RS05885 (1198313) 1198313..1198720 - 408 WP_224571294.1 tyrosine-type recombinase/integrase -
IUJ47_RS05890 (1198787) 1198787..1199287 - 501 WP_002363039.1 HAD family hydrolase -
IUJ47_RS05895 (1199292) 1199292..1200059 - 768 WP_002355416.1 DeoR/GlpR family DNA-binding transcription regulator -
IUJ47_RS05900 (1200546) 1200546..1200971 + 426 WP_002355418.1 galactose-6-phosphate isomerase subunit LacA -
IUJ47_RS05905 (1200988) 1200988..1201503 + 516 WP_002345825.1 galactose-6-phosphate isomerase subunit LacB -
IUJ47_RS05910 (1201514) 1201514..1202446 + 933 WP_002363040.1 tagatose-6-phosphate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-99)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11525.91 Da        Isoelectric Point: 5.7251

>T181003 WP_002355414.1 NZ_CP064374:1197925-1198233 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKHATSYSNQLVKLN

Download         Length: 309 bp

>T181003 NZ_CP085797:4505507-4505725 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT181003 WP_002326825.1 NZ_CP064374:1197651-1197923 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp

>AT181003 NZ_CP085797:4505105-4505479 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AE74

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References