180985

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 688938..689509 Replicon chromosome
Accession NZ_CP064374
Organism Enterococcus faecalis strain PartL-Efaecalis-RM8376

Toxin (Protein)


Gene name mazF Uniprot ID R3GRA7
Locus tag IUJ47_RS03350 Protein ID WP_002360937.1
Coordinates 688938..689279 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S4CGQ1
Locus tag IUJ47_RS03355 Protein ID WP_002367500.1
Coordinates 689279..689509 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ47_RS03345 (684953) 684953..688567 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
IUJ47_RS03350 (688938) 688938..689279 - 342 WP_002360937.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IUJ47_RS03355 (689279) 689279..689509 - 231 WP_002367500.1 hypothetical protein Antitoxin
IUJ47_RS03360 (689564) 689564..689743 - 180 WP_111997057.1 hypothetical protein -
IUJ47_RS03365 (689923) 689923..690138 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
IUJ47_RS03370 (690277) 690277..691269 + 993 WP_002389493.1 biotin--[acetyl-CoA-carboxylase] ligase -
IUJ47_RS03375 (691533) 691533..692171 - 639 WP_002378863.1 lytic polysaccharide monooxygenase -
IUJ47_RS03380 (692857) 692857..694473 + 1617 WP_002389442.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13165.41 Da        Isoelectric Point: 9.3988

>T180985 WP_002360937.1 NZ_CP064374:c689279-688938 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

>T180985 NZ_CP085796:2706615-2706770 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8704.69 Da        Isoelectric Point: 4.3313

>AT180985 WP_002367500.1 NZ_CP064374:c689509-689279 [Enterococcus faecalis]
MLTTKSRRQGNSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp

>AT180985 NZ_CP085796:c2706603-2706545 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2A7G9

Antitoxin

Source ID Structure
AlphaFold DB S4CGQ1

References