Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 26633..27276 | Replicon | plasmid unnamed3 |
| Accession | NZ_CP064371 | ||
| Organism | Klebsiella pneumoniae strain PartO-Kpneumoniae-RM8376 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | A0A421H508 |
| Locus tag | IUJ50_RS26385 | Protein ID | WP_001044773.1 |
| Coordinates | 26633..27049 (-) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | A0A060VSA5 |
| Locus tag | IUJ50_RS26390 | Protein ID | WP_001261277.1 |
| Coordinates | 27046..27276 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IUJ50_RS26360 (IUJ50_26300) | 24112..24477 | + | 366 | WP_025861963.1 | hypothetical protein | - |
| IUJ50_RS26365 (IUJ50_26305) | 24477..25057 | + | 581 | Protein_28 | transposase zinc-binding domain-containing protein | - |
| IUJ50_RS26370 (IUJ50_26310) | 25067..25777 | + | 711 | Protein_29 | IS110 family transposase | - |
| IUJ50_RS26375 (IUJ50_26315) | 25991..26146 | + | 156 | WP_164993475.1 | hypothetical protein | - |
| IUJ50_RS26380 (IUJ50_26320) | 26134..26574 | + | 441 | Protein_31 | transposase family protein | - |
| IUJ50_RS26385 (IUJ50_26325) | 26633..27049 | - | 417 | WP_001044773.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| IUJ50_RS26390 (IUJ50_26330) | 27046..27276 | - | 231 | WP_001261277.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| IUJ50_RS26395 (IUJ50_26335) | 27419..27691 | - | 273 | WP_044246604.1 | DNA polymerase III subunit theta | - |
| IUJ50_RS26400 (IUJ50_26340) | 27879..28070 | - | 192 | WP_001568047.1 | hypothetical protein | - |
| IUJ50_RS26405 (IUJ50_26345) | 28113..28619 | - | 507 | WP_013214014.1 | antirestriction protein ArdA | - |
| IUJ50_RS26410 (IUJ50_26350) | 28662..29090 | - | 429 | WP_004152356.1 | antirestriction protein | - |
| IUJ50_RS26415 (IUJ50_26355) | 29771..30538 | - | 768 | WP_025861961.1 | hypothetical protein | - |
| IUJ50_RS26420 (IUJ50_26360) | 30592..31011 | - | 420 | WP_025861960.1 | DUF1380 family protein | - |
| IUJ50_RS26425 (IUJ50_26365) | 31021..31242 | - | 222 | WP_025861959.1 | hypothetical protein | - |
| IUJ50_RS26430 (IUJ50_26370) | 31242..31943 | - | 702 | WP_001568041.1 | DNA methylase | - |
| IUJ50_RS26435 | 32015..32184 | - | 170 | Protein_42 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | vat / iroB / rmpA | 1..96086 | 96086 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15227.68 Da Isoelectric Point: 7.7805
>T180968 WP_001044773.1 NZ_CP064371:c27049-26633 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPETVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK
VNKTYMLDTCICSFIMREQPETVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK
Download Length: 417 bp
>T180968 NZ_CP085795:1863295-1863582 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8899.03 Da Isoelectric Point: 4.5112
>AT180968 WP_001261277.1 NZ_CP064371:c27276-27046 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVRELEIIREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL
MRTVSIFKNGNNRAIRLPRDLDFEGVRELEIIREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL
Download Length: 231 bp
>AT180968 NZ_CP085795:1863569-1863871 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAGCATGGTTAAACATAAACGCGGCAATGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG
ATGAGCATGGTTAAACATAAACGCGGCAATGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A421H508 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A060VSA5 |