Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 12052..12577 | Replicon | plasmid unnamed3 |
| Accession | NZ_CP064371 | ||
| Organism | Klebsiella pneumoniae strain PartO-Kpneumoniae-RM8376 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | D4HQE7 |
| Locus tag | IUJ50_RS26320 | Protein ID | WP_013023785.1 |
| Coordinates | 12272..12577 (+) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | A0A378F352 |
| Locus tag | IUJ50_RS26315 | Protein ID | WP_025862266.1 |
| Coordinates | 12052..12270 (+) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IUJ50_RS26270 (IUJ50_26215) | 7338..8282 | + | 945 | WP_004150724.1 | GTP cyclohydrolase FolE2 | - |
| IUJ50_RS26275 (IUJ50_26220) | 8509..9073 | + | 565 | Protein_10 | threonine--tRNA ligase | - |
| IUJ50_RS26280 | 8997..9299 | + | 303 | WP_227499864.1 | hypothetical protein | - |
| IUJ50_RS26285 (IUJ50_26230) | 9233..9793 | + | 561 | Protein_12 | porphobilinogen synthase | - |
| IUJ50_RS26290 (IUJ50_26235) | 10394..10729 | - | 336 | Protein_13 | transposase | - |
| IUJ50_RS26295 (IUJ50_26240) | 10917..11171 | - | 255 | WP_025862265.1 | hypothetical protein | - |
| IUJ50_RS26300 (IUJ50_26245) | 11230..11487 | - | 258 | WP_004098928.1 | hypothetical protein | - |
| IUJ50_RS26305 (IUJ50_26250) | 11536..11739 | - | 204 | WP_004150739.1 | HHA domain-containing protein | - |
| IUJ50_RS26310 | 11733..11843 | + | 111 | Protein_17 | hypothetical protein | - |
| IUJ50_RS26315 (IUJ50_26255) | 12052..12270 | + | 219 | WP_025862266.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| IUJ50_RS26320 (IUJ50_26260) | 12272..12577 | + | 306 | WP_013023785.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| IUJ50_RS26325 (IUJ50_26265) | 12607..12840 | + | 234 | WP_025862267.1 | hypothetical protein | - |
| IUJ50_RS26330 (IUJ50_26270) | 12833..13627 | + | 795 | WP_025862268.1 | site-specific integrase | - |
| IUJ50_RS26335 (IUJ50_26275) | 14134..14214 | - | 81 | WP_072058407.1 | hypothetical protein | - |
| IUJ50_RS26340 (IUJ50_26280) | 14351..14845 | - | 495 | Protein_23 | helix-turn-helix domain-containing protein | - |
| IUJ50_RS26345 (IUJ50_26285) | 14969..15124 | - | 156 | WP_004150747.1 | type I toxin-antitoxin system Hok family toxin | - |
| IUJ50_RS26350 (IUJ50_26290) | 15322..15699 | - | 378 | WP_162985544.1 | M15 family metallopeptidase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | vat / iroB / rmpA | 1..96086 | 96086 | |
| - | flank | IS/Tn | - | - | 14333..14845 | 512 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11615.30 Da Isoelectric Point: 6.4672
>T180967 WP_013023785.1 NZ_CP064371:12272-12577 [Klebsiella pneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI
Download Length: 306 bp
>T180967 NZ_CP085795:1819302-1819610 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8420.39 Da Isoelectric Point: 4.7405
>AT180967 WP_025862266.1 NZ_CP064371:12052-12270 [Klebsiella pneumoniae]
MKQRITVTIDSDSYQLLKSADVNISVLVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW
MKQRITVTIDSDSYQLLKSADVNISVLVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW
Download Length: 219 bp
>AT180967 NZ_CP085795:1819060-1819299 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4ZZW6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A378F352 |