Detailed information of TA system
Overview
TA module
Type | II | Classification (family/domain) | vagCD/VapC-VagC |
Location | 96959..97602 | Replicon | plasmid unnamed2 |
Accession | NZ_CP064370 | ||
Organism | Klebsiella pneumoniae strain PartO-Kpneumoniae-RM8376 |
Toxin (Protein)
Gene name | vagD | Uniprot ID | A0A377VRY2 |
Locus tag | IUJ50_RS26185 | Protein ID | WP_025862278.1 |
Coordinates | 96959..97375 (-) | Length | 139 a.a. |
Antitoxin (Protein)
Gene name | vagC | Uniprot ID | A0A378P8I1 |
Locus tag | IUJ50_RS26190 | Protein ID | WP_032444058.1 |
Coordinates | 97372..97602 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
IUJ50_RS26150 (IUJ50_26100) | 92235..92408 | - | 174 | WP_153810823.1 | hypothetical protein | - |
IUJ50_RS26155 (IUJ50_26105) | 92456..93676 | - | 1221 | WP_004150696.1 | ISL3 family transposase | - |
IUJ50_RS26160 (IUJ50_26110) | 93687..94664 | - | 978 | WP_032444059.1 | cytochrome P450 | - |
IUJ50_RS26165 (IUJ50_26115) | 94657..96003 | - | 1347 | WP_071531407.1 | radical SAM protein | - |
IUJ50_RS26170 (IUJ50_26120) | 96027..96442 | - | 416 | Protein_120 | IS1 family transposase | - |
IUJ50_RS26175 (IUJ50_26125) | 96498..96695 | + | 198 | Protein_121 | IS1 family transposase | - |
IUJ50_RS26180 (IUJ50_26130) | 96730..96924 | - | 195 | WP_032444079.1 | hypothetical protein | - |
IUJ50_RS26185 (IUJ50_26135) | 96959..97375 | - | 417 | WP_025862278.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
IUJ50_RS26190 (IUJ50_26140) | 97372..97602 | - | 231 | WP_032444058.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
IUJ50_RS26195 (IUJ50_26145) | 97972..99207 | - | 1236 | WP_004150704.1 | RhtX/FptX family siderophore transporter | - |
IUJ50_RS26200 (IUJ50_26150) | 99211..100632 | - | 1422 | WP_025862276.1 | PepSY-associated TM helix domain-containing protein | - |
IUJ50_RS26205 (IUJ50_26155) | 100629..100877 | - | 249 | WP_025862275.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | - | pilW | 1..105919 | 105919 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15005.49 Da Isoelectric Point: 8.5441
>T180966 WP_025862278.1 NZ_CP064370:c97375-96959 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKTSPRHIQLVDAFCARLDAILPWDRA
AVDATTGIRVALRLAGTPIGPNDTAIAGHPIAAGAVLVTNNVREFARVPGLVLEDWVE
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKTSPRHIQLVDAFCARLDAILPWDRA
AVDATTGIRVALRLAGTPIGPNDTAIAGHPIAAGAVLVTNNVREFARVPGLVLEDWVE
Download Length: 417 bp
>T180966 NZ_CP085795:1778201-1778485 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGCAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGCAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG
Antitoxin
Download Length: 77 a.a. Molecular weight: 8748.81 Da Isoelectric Point: 4.8011
>AT180966 WP_032444058.1 NZ_CP064370:c97602-97372 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSEQEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAERENVVSDEGRFKP
MRTVSIFKNGNNRAIRLPRDLDFEGVSEQEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAERENVVSDEGRFKP
Download Length: 231 bp
>AT180966 NZ_CP085795:1777969-1778211 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A377VRY2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A378P8I1 |