Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 96959..97602 Replicon plasmid unnamed2
Accession NZ_CP064370
Organism Klebsiella pneumoniae strain PartO-Kpneumoniae-RM8376

Toxin (Protein)


Gene name vagD Uniprot ID A0A377VRY2
Locus tag IUJ50_RS26185 Protein ID WP_025862278.1
Coordinates 96959..97375 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A378P8I1
Locus tag IUJ50_RS26190 Protein ID WP_032444058.1
Coordinates 97372..97602 (-) Length 77 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ50_RS26150 (IUJ50_26100) 92235..92408 - 174 WP_153810823.1 hypothetical protein -
IUJ50_RS26155 (IUJ50_26105) 92456..93676 - 1221 WP_004150696.1 ISL3 family transposase -
IUJ50_RS26160 (IUJ50_26110) 93687..94664 - 978 WP_032444059.1 cytochrome P450 -
IUJ50_RS26165 (IUJ50_26115) 94657..96003 - 1347 WP_071531407.1 radical SAM protein -
IUJ50_RS26170 (IUJ50_26120) 96027..96442 - 416 Protein_120 IS1 family transposase -
IUJ50_RS26175 (IUJ50_26125) 96498..96695 + 198 Protein_121 IS1 family transposase -
IUJ50_RS26180 (IUJ50_26130) 96730..96924 - 195 WP_032444079.1 hypothetical protein -
IUJ50_RS26185 (IUJ50_26135) 96959..97375 - 417 WP_025862278.1 type II toxin-antitoxin system VapC family toxin Toxin
IUJ50_RS26190 (IUJ50_26140) 97372..97602 - 231 WP_032444058.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
IUJ50_RS26195 (IUJ50_26145) 97972..99207 - 1236 WP_004150704.1 RhtX/FptX family siderophore transporter -
IUJ50_RS26200 (IUJ50_26150) 99211..100632 - 1422 WP_025862276.1 PepSY-associated TM helix domain-containing protein -
IUJ50_RS26205 (IUJ50_26155) 100629..100877 - 249 WP_025862275.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - pilW 1..105919 105919


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-129)

Antitoxin

(7-49)


Sequences


Toxin        


Download         Length: 139 a.a.        Molecular weight: 15005.49 Da        Isoelectric Point: 8.5441

>T180966 WP_025862278.1 NZ_CP064370:c97375-96959 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKTSPRHIQLVDAFCARLDAILPWDRA
AVDATTGIRVALRLAGTPIGPNDTAIAGHPIAAGAVLVTNNVREFARVPGLVLEDWVE

Download         Length: 417 bp

>T180966 NZ_CP085795:1778201-1778485 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGCAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8748.81 Da        Isoelectric Point: 4.8011

>AT180966 WP_032444058.1 NZ_CP064370:c97602-97372 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSEQEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAERENVVSDEGRFKP

Download         Length: 231 bp

>AT180966 NZ_CP085795:1777969-1778211 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A377VRY2


Antitoxin

Source ID Structure
AlphaFold DB A0A378P8I1

References