180964

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 993..1467 Replicon plasmid unnamed1
Accession NZ_CP064369
Organism Klebsiella pneumoniae strain PartO-Kpneumoniae-RM8376

Toxin (Protein)


Gene name pasB Uniprot ID S1DZ70
Locus tag IUJ50_RS25490 Protein ID WP_000262326.1
Coordinates 1201..1467 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID S1EJF5
Locus tag IUJ50_RS25485 Protein ID WP_000879771.1
Coordinates 993..1217 (+) Length 75 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ50_RS25485 (IUJ50_25445) 993..1217 + 225 WP_000879771.1 DUF6290 family protein Antitoxin
IUJ50_RS25490 (IUJ50_25450) 1201..1467 + 267 WP_000262326.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IUJ50_RS25495 (IUJ50_25460) 2092..3780 + 1689 WP_000012966.1 colicin-like bacteriocin tRNase domain-containing protein -
IUJ50_RS25500 (IUJ50_25465) 3790..4047 + 258 WP_000523382.1 colicin E3-like toxin immunity protein -
IUJ50_RS25505 (IUJ50_25470) 4132..4281 + 150 WP_002193747.1 colicin release lysis protein -
IUJ50_RS25510 5766..6131 + 366 WP_000483454.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..13285 13285


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-87)

Antitoxin

(4-45)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10385.00 Da        Isoelectric Point: 9.5211

>T180964 WP_000262326.1 NZ_CP064369:1201-1467 [Klebsiella pneumoniae]
MVWTINYSDRALKSLRKMDKQNARRIVDFMDLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRILCEIRDDELVILAATI
GHRREVYD

Download         Length: 267 bp

>T180964 NZ_CP085795:1361855-1362166 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8369.28 Da        Isoelectric Point: 4.6533

>AT180964 WP_000879771.1 NZ_CP064369:993-1217 [Klebsiella pneumoniae]
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD

Download         Length: 225 bp

>AT180964 NZ_CP085795:1362167-1362457 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1DZ70


Antitoxin

Source ID Structure
AlphaFold DB S1EJF5

References