Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3986573..3987230 Replicon chromosome
Accession NZ_CP064368
Organism Klebsiella pneumoniae strain PartO-Kpneumoniae-RM8376

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag IUJ50_RS19385 Protein ID WP_002916310.1
Coordinates 3986820..3987230 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag IUJ50_RS19380 Protein ID WP_002916312.1
Coordinates 3986573..3986839 (+) Length 89 a.a.

Genomic Context

IUJ50_RS19365IUJ50_RS19370IUJ50_RS19380IUJ50_RS19385IUJ50_RS19395IUJ50_RS19400IUJ50_RS19405IUJ50_RS19355IUJ50_RS19360IUJ50_RS19375IUJ50_RS19390
Location: 3984111..3984422 (312 bp)
Type: Others
Protein ID: WP_004144734.1
Location: 3984586..3985245 (660 bp)
Type: Others
Protein ID: WP_002916317.1
Location: 3986573..3986839 (267 bp)
Type: Antitoxin
Protein ID: WP_002916312.1
Location: 3986820..3987230 (411 bp)
Type: Toxin
Protein ID: WP_002916310.1
Location: 3987859..3988755 (897 bp)
Type: Others
Protein ID: WP_004144729.1
Location: 3988778..3989491 (714 bp)
Type: Others
Protein ID: WP_004174456.1
Location: 3989497..3991230 (1734 bp)
Type: Others
Protein ID: WP_004149758.1
Location: 3981781..3983214 (1434 bp)
Type: Others
Protein ID: WP_025861871.1
Location: 3983333..3984061 (729 bp)
Type: Others
Protein ID: WP_002916321.1
Location: 3985344..3986327 (984 bp)
Type: Others
Protein ID: WP_002916313.1
Location: 3987237..3987758 (522 bp)
Type: Others
Protein ID: WP_002916308.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IUJ50_RS19355 (3981781)3981781..3983214-1434WP_025861871.16-phospho-beta-glucosidase-
IUJ50_RS19360 (3983333)3983333..3984061-729WP_002916321.1MurR/RpiR family transcriptional regulator-
IUJ50_RS19365 (3984111)3984111..3984422+312WP_004144734.1N(4)-acetylcytidine aminohydrolase-
IUJ50_RS19370 (3984586)3984586..3985245+660WP_002916317.1hemolysin III family protein-
IUJ50_RS19375 (3985344)3985344..3986327-984WP_002916313.1tRNA-modifying protein YgfZ-
IUJ50_RS19380 (3986573)3986573..3986839+267WP_002916312.1FAD assembly factor SdhEAntitoxin
IUJ50_RS19385 (3986820)3986820..3987230+411WP_002916310.1protein YgfXToxin
IUJ50_RS19390 (3987237)3987237..3987758-522WP_002916308.1flavodoxin FldB-
IUJ50_RS19395 (3987859)3987859..3988755+897WP_004144729.1site-specific tyrosine recombinase XerD-
IUJ50_RS19400 (3988778)3988778..3989491+714WP_004174456.1bifunctional protein-disulfide isomerase/oxidoreductase DsbC-
IUJ50_RS19405 (3989497)3989497..3991230+1734WP_004149758.1single-stranded-DNA-specific exonuclease RecJ-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T180955 WP_002916310.1 NZ_CP064368:3986820-3987230 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T180955 NZ_CP085794:3157248-3157351 [Salmonella enterica subsp. enterica serovar Enteritidis]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT180955 WP_002916312.1 NZ_CP064368:3986573-3986839 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT180955 NZ_CP085794:c3157353-3157208 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3GSW7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3GY41

References