Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3986573..3987230 Replicon chromosome
Accession NZ_CP064368
Organism Klebsiella pneumoniae strain PartO-Kpneumoniae-RM8376

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag IUJ50_RS19385 Protein ID WP_002916310.1
Coordinates 3986820..3987230 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag IUJ50_RS19380 Protein ID WP_002916312.1
Coordinates 3986573..3986839 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ50_RS19355 (3981781) 3981781..3983214 - 1434 WP_025861871.1 6-phospho-beta-glucosidase -
IUJ50_RS19360 (3983333) 3983333..3984061 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
IUJ50_RS19365 (3984111) 3984111..3984422 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
IUJ50_RS19370 (3984586) 3984586..3985245 + 660 WP_002916317.1 hemolysin III family protein -
IUJ50_RS19375 (3985344) 3985344..3986327 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
IUJ50_RS19380 (3986573) 3986573..3986839 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
IUJ50_RS19385 (3986820) 3986820..3987230 + 411 WP_002916310.1 protein YgfX Toxin
IUJ50_RS19390 (3987237) 3987237..3987758 - 522 WP_002916308.1 flavodoxin FldB -
IUJ50_RS19395 (3987859) 3987859..3988755 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
IUJ50_RS19400 (3988778) 3988778..3989491 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IUJ50_RS19405 (3989497) 3989497..3991230 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T180955 WP_002916310.1 NZ_CP064368:3986820-3987230 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T180955 NZ_CP085794:3157248-3157351 [Salmonella enterica subsp. enterica serovar Enteritidis]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT180955 WP_002916312.1 NZ_CP064368:3986573-3986839 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT180955 NZ_CP085794:c3157353-3157208 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References