Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2614972..2615488 Replicon chromosome
Accession NZ_CP064368
Organism Klebsiella pneumoniae strain PartO-Kpneumoniae-RM8376

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag IUJ50_RS12680 Protein ID WP_002886902.1
Coordinates 2614972..2615256 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag IUJ50_RS12685 Protein ID WP_002886901.1
Coordinates 2615246..2615488 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ50_RS12655 (2610455) 2610455..2610718 - 264 WP_025368518.1 PTS sugar transporter subunit IIB -
IUJ50_RS12660 (2610848) 2610848..2611021 + 174 WP_004146781.1 hypothetical protein -
IUJ50_RS12665 (2611024) 2611024..2611767 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
IUJ50_RS12670 (2612124) 2612124..2614262 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
IUJ50_RS12675 (2614504) 2614504..2614968 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
IUJ50_RS12680 (2614972) 2614972..2615256 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IUJ50_RS12685 (2615246) 2615246..2615488 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IUJ50_RS12690 (2615566) 2615566..2617476 - 1911 WP_004146774.1 PRD domain-containing protein -
IUJ50_RS12695 (2617499) 2617499..2618653 - 1155 WP_004146773.1 lactonase family protein -
IUJ50_RS12700 (2618720) 2618720..2619460 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T180951 WP_002886902.1 NZ_CP064368:c2615256-2614972 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T180951 NZ_CP085794:1819181-1819489 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT180951 WP_002886901.1 NZ_CP064368:c2615488-2615246 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT180951 NZ_CP085794:1818939-1819178 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References