Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1867787..1868406 Replicon chromosome
Accession NZ_CP064368
Organism Klebsiella pneumoniae strain PartO-Kpneumoniae-RM8376

Toxin (Protein)


Gene name Hha Uniprot ID A0A377W829
Locus tag IUJ50_RS09100 Protein ID WP_025861658.1
Coordinates 1868188..1868406 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag IUJ50_RS09095 Protein ID WP_002892066.1
Coordinates 1867787..1868161 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ50_RS09085 (1862939) 1862939..1864132 + 1194 WP_004147376.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IUJ50_RS09090 (1864155) 1864155..1867301 + 3147 WP_004147373.1 multidrug efflux RND transporter permease subunit AcrB -
IUJ50_RS09095 (1867787) 1867787..1868161 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
IUJ50_RS09100 (1868188) 1868188..1868406 + 219 WP_025861658.1 HHA domain-containing protein Toxin
IUJ50_RS09105 (1868565) 1868565..1869131 + 567 WP_032443798.1 maltose O-acetyltransferase -
IUJ50_RS09110 (1869103) 1869103..1869243 - 141 WP_004147370.1 hypothetical protein -
IUJ50_RS09115 (1869264) 1869264..1869734 + 471 WP_002892026.1 YlaC family protein -
IUJ50_RS09120 (1869709) 1869709..1871160 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
IUJ50_RS09125 (1871261) 1871261..1871959 + 699 WP_025861660.1 GNAT family protein -
IUJ50_RS09130 (1871956) 1871956..1872096 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
IUJ50_RS09135 (1872096) 1872096..1872359 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8644.00 Da        Isoelectric Point: 8.9008

>T180948 WP_025861658.1 NZ_CP064368:1868188-1868406 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELSVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T180948 NZ_CP085794:1361734-1362045 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT180948 WP_002892066.1 NZ_CP064368:1867787-1868161 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT180948 NZ_CP085794:1362046-1362336 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377W829

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References