Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1882761..1883537 Replicon chromosome
Accession NZ_CP064365
Organism Staphylococcus aureus strain PartF-Saureus-RM8376

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag IUJ41_RS09525 Protein ID WP_000031108.1
Coordinates 1883385..1883537 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag IUJ41_RS09520 Protein ID WP_001251224.1
Coordinates 1882761..1883360 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ41_RS09500 (IUJ41_09470) 1878677..1880134 + 1458 WP_000649907.1 ABC transporter permease subunit -
IUJ41_RS09505 (IUJ41_09475) 1880127..1880849 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
IUJ41_RS09510 (IUJ41_09480) 1881000..1882127 + 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
IUJ41_RS09515 (IUJ41_09485) 1882132..1882602 + 471 WP_000181398.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
IUJ41_RS09520 (IUJ41_09490) 1882761..1883360 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
IUJ41_RS09525 (IUJ41_09495) 1883385..1883537 + 153 WP_000031108.1 SAS053 family protein Toxin
IUJ41_RS09530 (IUJ41_09500) 1884314..1884709 + 396 WP_000901021.1 hypothetical protein -
IUJ41_RS09535 (IUJ41_09505) 1884905..1886290 + 1386 WP_000116224.1 class II fumarate hydratase -
IUJ41_RS09540 (IUJ41_09510) 1886753..1887574 - 822 WP_000669376.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T180944 WP_000031108.1 NZ_CP064365:1883385-1883537 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T180944 NZ_CP085794:c812044-811769 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT180944 WP_001251224.1 NZ_CP064365:1882761-1883360 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT180944 NZ_CP085794:c812307-812047 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCACGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References