Detailed information of TA system TA180943

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 1724994..1725523
• Replicon: chromosome
• Accession: NZ_CP064365
• Organism: Staphylococcus aureus strain PartF-Saureus-RM8376

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: IUJ41_RS08610
• Protein ID: WP_000621175.1
• Coordinates: 1725161..1725523 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: IUJ41_RS08605
• Protein ID: WP_000948331.1
• Coordinates: 1724994..1725164 (+)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IUJ41_RS08575 (IUJ41_08540)	1720030..1720590	+	561	WP_001092411.1	K(+)-transporting ATPase subunit C	-
IUJ41_RS08580 (IUJ41_08545)	1720799..1721278	+	480	WP_001287088.1	hypothetical protein	-
IUJ41_RS08585 (IUJ41_08550)	1721271..1722854	+	1584	WP_001294626.1	PH domain-containing protein	-
IUJ41_RS08590 (IUJ41_08555)	1722841..1723332	+	492	WP_001205910.1	PH domain-containing protein	-
IUJ41_RS08595 (IUJ41_08560)	1723336..1723695	+	360	WP_000581200.1	holo-ACP synthase	-
IUJ41_RS08600 (IUJ41_08565)	1723761..1724909	+	1149	WP_001281145.1	alanine racemase	-
IUJ41_RS08605 (IUJ41_08570)	1724994..1725164	+	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
IUJ41_RS08610 (IUJ41_08575)	1725161..1725523	+	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
IUJ41_RS08615 (IUJ41_08580)	1725871..1726872	+	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
IUJ41_RS08620 (IUJ41_08585)	1726991..1727317	+	327	WP_001052491.1	anti-sigma factor antagonist	-
IUJ41_RS08625 (IUJ41_08590)	1727319..1727798	+	480	WP_001190829.1	anti-sigma B factor RsbW	-
IUJ41_RS08630 (IUJ41_08595)	1727773..1728543	+	771	WP_001041103.1	RNA polymerase sigma factor SigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T180943 WP_000621175.1 NZ_CP064365:1725161-1725523 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T180943 NZ_CP085794:c345717-345304 [Salmonella enterica subsp. enterica serovar Enteritidis]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT180943 WP_000948331.1 NZ_CP064365:1724994-1725164 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT180943 NZ_CP085794:c345964-345698 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1