Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1705252..1705766 Replicon chromosome
Accession NZ_CP064365
Organism Staphylococcus aureus strain PartF-Saureus-RM8376

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IUJ41_RS08520 Protein ID WP_000581792.1
Coordinates 1705557..1705766 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IUJ41_RS08515 Protein ID WP_000138932.1
Coordinates 1705252..1705545 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ41_RS08495 (IUJ41_08460) 1700515..1701156 + 642 WP_000483153.1 thiamine phosphate synthase -
IUJ41_RS08500 (IUJ41_08465) 1701242..1702114 + 873 WP_000725802.1 membrane protein insertase YidC -
IUJ41_RS08505 (IUJ41_08470) 1702927..1703574 - 648 WP_001187629.1 HD domain-containing protein -
IUJ41_RS08510 (IUJ41_08475) 1703602..1705086 - 1485 WP_000571549.1 cardiolipin synthase -
IUJ41_RS08515 (IUJ41_08480) 1705252..1705545 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IUJ41_RS08520 (IUJ41_08485) 1705557..1705766 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IUJ41_RS08525 (IUJ41_08490) 1705894..1706031 + 138 WP_000828354.1 Lmo0850 family protein -
IUJ41_RS08530 (IUJ41_08495) 1706295..1707497 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IUJ41_RS08535 (IUJ41_08500) 1707815..1708885 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IUJ41_RS08540 (IUJ41_08505) 1708900..1710258 + 1359 WP_000611465.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T180942 WP_000581792.1 NZ_CP064365:1705557-1705766 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T180942 NZ_CP085794:c334813-334415 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT180942 WP_000138932.1 NZ_CP064365:1705252-1705545 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT180942 NZ_CP085794:c335040-334813 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References