Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 216301..216778 Replicon chromosome
Accession NZ_CP064365
Organism Staphylococcus aureus strain PartF-Saureus-RM8376

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag IUJ41_RS01240 Protein ID WP_000052078.1
Coordinates 216590..216778 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IUJ41_RS01235 Protein ID WP_001059690.1
Coordinates 216301..216561 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ41_RS01200 (IUJ41_01190) 211694..212410 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
IUJ41_RS01205 (IUJ41_01195) 212558..212980 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
IUJ41_RS01210 (IUJ41_01200) 213379..213873 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
IUJ41_RS01215 (IUJ41_01205) 214028..214645 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
IUJ41_RS01220 (IUJ41_01210) 214718..215299 - 582 WP_001140693.1 histidine phosphatase family protein -
IUJ41_RS01225 (IUJ41_01215) 215524..215760 + 237 WP_000368687.1 hypothetical protein -
IUJ41_RS01230 (IUJ41_01220) 215757..215960 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
IUJ41_RS01235 (IUJ41_01225) 216301..216561 + 261 WP_001059690.1 hypothetical protein Antitoxin
IUJ41_RS01240 (IUJ41_01230) 216590..216778 + 189 WP_000052078.1 hypothetical protein Toxin
IUJ41_RS01245 (IUJ41_01235) 216966..217535 + 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
IUJ41_RS01250 (IUJ41_01240) 217623..217907 + 285 WP_001004395.1 hypothetical protein -
IUJ41_RS01255 (IUJ41_01245) 217969..218187 + 219 WP_000005886.1 hypothetical protein -
IUJ41_RS01260 (IUJ41_01250) 218683..218883 - 201 WP_001059082.1 cold-shock protein -
IUJ41_RS01265 (IUJ41_01255) 219240..219926 - 687 WP_001548082.1 thermonuclease family protein -
IUJ41_RS01270 (IUJ41_01260) 220267..220737 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp 153124..230377 77253


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T180933 WP_000052078.1 NZ_CP064365:216590-216778 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T180933 NZ_CP085793:1841509-1841612 [Salmonella enterica subsp. enterica serovar Enteritidis]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT180933 WP_001059690.1 NZ_CP064365:216301-216561 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT180933 NZ_CP085793:c1841614-1841469 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References