Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1398014..1398626 Replicon chromosome
Accession NZ_CP064364
Organism Streptococcus pyogenes strain PartK-Spyogenes-RM8376

Toxin (Protein)


Gene name parE Uniprot ID J7M9F1
Locus tag IUJ46_RS07220 Protein ID WP_010922665.1
Coordinates 1398291..1398626 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag IUJ46_RS07215 Protein ID WP_002988079.1
Coordinates 1398014..1398301 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ46_RS07190 (IUJ46_07155) 1393191..1394174 - 984 WP_002982755.1 tagatose-bisphosphate aldolase -
IUJ46_RS07195 (IUJ46_07160) 1394178..1395107 - 930 WP_010922663.1 tagatose-6-phosphate kinase -
IUJ46_RS07200 (IUJ46_07165) 1395155..1395670 - 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
IUJ46_RS07205 (IUJ46_07170) 1395705..1396133 - 429 WP_010922664.1 galactose-6-phosphate isomerase subunit LacA -
IUJ46_RS07210 (IUJ46_07175) 1396580..1397353 + 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
IUJ46_RS07215 (IUJ46_07180) 1398014..1398301 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
IUJ46_RS07220 (IUJ46_07185) 1398291..1398626 + 336 WP_010922665.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IUJ46_RS07225 1398724..1399731 + 1008 Protein_1424 site-specific integrase -
IUJ46_RS07230 (IUJ46_07200) 1399851..1400243 - 393 WP_002982716.1 30S ribosomal protein S9 -
IUJ46_RS07235 (IUJ46_07205) 1400264..1400710 - 447 WP_002982710.1 50S ribosomal protein L13 -
IUJ46_RS07240 (IUJ46_07210) 1400928..1401134 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
IUJ46_RS07245 (IUJ46_07215) 1401131..1401637 - 507 WP_002988070.1 hypothetical protein -
IUJ46_RS07250 (IUJ46_07220) 1401773..1402633 - 861 WP_002982687.1 DegV family protein -
IUJ46_RS07255 (IUJ46_07225) 1402730..1403248 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13185.99 Da        Isoelectric Point: 5.2144

>T180931 WP_010922665.1 NZ_CP064364:1398291-1398626 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRIVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T180931 NZ_CP085793:c932638-932381 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCAAAACCCACATGACCACCTATTACTCACAAATCCCCAGCCT
GCATCTTAAGGGCGACTGGCTGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAGCAGCTTTATCAGGCTAAACAGGTGGTTAAGGGAATT
AAGGACGTGCTGGTTTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT180931 WP_002988079.1 NZ_CP064364:1398014-1398301 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT180931 NZ_CP085793:932463-932795 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J7M9F1

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References