Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3742347..3742967 Replicon chromosome
Accession NZ_CP064363
Organism Salmonella enterica subsp. arizonae strain PartD-Sarizonae-RM8376

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag IUJ39_RS18175 Protein ID WP_001280991.1
Coordinates 3742347..3742565 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A741MU25
Locus tag IUJ39_RS18180 Protein ID WP_000344793.1
Coordinates 3742593..3742967 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ39_RS18135 (3737570) 3737570..3738139 + 570 WP_000779801.1 YbaY family lipoprotein -
IUJ39_RS18140 (3738172) 3738172..3738561 - 390 WP_000961285.1 MGMT family protein -
IUJ39_RS18150 (3738792) 3738792..3740342 - 1551 WP_140197772.1 EAL domain-containing protein -
IUJ39_RS18155 (3740567) 3740567..3740827 + 261 WP_000801420.1 type B 50S ribosomal protein L31 -
IUJ39_RS18160 (3740833) 3740833..3740973 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
IUJ39_RS18165 (3741029) 3741029..3741499 - 471 WP_000136186.1 YlaC family protein -
IUJ39_RS18170 (3741617) 3741617..3742168 - 552 WP_140197773.1 maltose O-acetyltransferase -
IUJ39_RS18175 (3742347) 3742347..3742565 - 219 WP_001280991.1 HHA domain-containing protein Toxin
IUJ39_RS18180 (3742593) 3742593..3742967 - 375 WP_000344793.1 Hha toxicity modulator TomB Antitoxin
IUJ39_RS18185 (3743466) 3743466..3746615 - 3150 WP_001132516.1 efflux RND transporter permease AcrB -
IUJ39_RS18190 (3746638) 3746638..3747831 - 1194 WP_140197774.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T180930 WP_001280991.1 NZ_CP064363:c3742565-3742347 [Salmonella enterica subsp. arizonae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T180930 NZ_CP085793:547296-547583 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14380.17 Da        Isoelectric Point: 4.8673

>AT180930 WP_000344793.1 NZ_CP064363:c3742967-3742593 [Salmonella enterica subsp. arizonae]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGLVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRQSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT180930 NZ_CP085793:547570-547872 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAGCATGGTTAAACATAAACGCGGCAATGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A741MU25

References