Detailed information of TA system TA180929

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 3109160..3109676
• Replicon: chromosome
• Accession: NZ_CP064363
• Organism: Salmonella enterica subsp. arizonae strain PartD-Sarizonae-RM8376

Toxin (Protein)

• Gene name: relE
• Uniprot ID: V1HEI0
• Locus tag: IUJ39_RS15110
• Protein ID: WP_000220584.1
• Coordinates: 3109392..3109676 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V1HDU1
• Locus tag: IUJ39_RS15105
• Protein ID: WP_023182636.1
• Coordinates: 3109160..3109402 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IUJ39_RS15070 (3105013)	3105013..3105564	-	552	WP_000166292.1	ribosome biogenesis factor YjgA	-
IUJ39_RS15075 (3105660)	3105660..3107012	+	1353	WP_038397075.1	metalloprotease PmbA	-
IUJ39_RS15080 (3107061)	3107061..3107447	+	387	WP_038397074.1	cytochrome b562	-
IUJ39_RS15085 (3107735)	3107735..3108073	+	339	WP_140198334.1	glycine dehydrogenase	-
IUJ39_RS15090 (3108084)	3108084..3108446	+	363	WP_140198335.1	SFCGS family glycine-rich protein	-
IUJ39_RS15095 (3108446)	3108446..3108748	+	303	WP_024132044.1	DUF4312 family protein	-
IUJ39_RS15100 (3108833)	3108833..3109081	+	249	Protein_2939	transcription antiterminator BglG	-
IUJ39_RS15105 (3109160)	3109160..3109402	+	243	WP_023182636.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
IUJ39_RS15110 (3109392)	3109392..3109676	+	285	WP_000220584.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IUJ39_RS15115 (3109686)	3109686..3110150	-	465	WP_058819816.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
IUJ39_RS15120 (3110306)	3110306..3112444	-	2139	WP_000187814.1	anaerobic ribonucleoside-triphosphate reductase	-
IUJ39_RS15125 (3112853)	3112853..3114464	-	1612	Protein_2944	alpha,alpha-phosphotrehalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11085.02 Da
• Isoelectric Point: 10.3015

>T180929 WP_000220584.1 NZ_CP064363:3109392-3109676 [Salmonella enterica subsp. arizonae]
MTYELEFDPRALKEWQKLGETVKKQFRKKLVDVLSNPRVESARLRELPDCYKIKLKTSGYRLVYQVQDDVVLVVVIAIGK
REKSAVYRQADKRL

Nucleotide

• Length: 285 bp

>T180929 NZ_CP085793:503307-503615 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9013.38 Da
• Isoelectric Point: 5.0651

>AT180929 WP_023182636.1 NZ_CP064363:3109160-3109402 [Salmonella enterica subsp. arizonae]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTVTISDSEDALLQTVRERLANPQKGIRVSLDDL

Nucleotide

• Length: 243 bp

>AT180929 NZ_CP085793:503065-503304 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Structures

Toxin

• AlphaFold DB: A0A741MVA9