Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1808481..1809071 Replicon chromosome
Accession NZ_CP064363
Organism Salmonella enterica subsp. arizonae strain PartD-Sarizonae-RM8376

Toxin (Protein)


Gene name pemK Uniprot ID A0A741MVU5
Locus tag IUJ39_RS09010 Protein ID WP_000373725.1
Coordinates 1808481..1808813 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A741N4R3
Locus tag IUJ39_RS09015 Protein ID WP_000288813.1
Coordinates 1808814..1809071 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ39_RS08990 (1804639) 1804639..1804953 + 315 WP_140197993.1 IS66 family insertion sequence element accessory protein TnpB -
IUJ39_RS08995 (1804940) 1804940..1805275 + 336 WP_038395648.1 IS66 family insertion sequence element accessory protein TnpB -
IUJ39_RS09000 (1805303) 1805303..1806874 + 1572 WP_140197994.1 IS66 family transposase -
IUJ39_RS09005 (1807194) 1807194..1807792 - 599 Protein_1764 integrase domain-containing protein -
IUJ39_RS09010 (1808481) 1808481..1808813 - 333 WP_000373725.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IUJ39_RS09015 (1808814) 1808814..1809071 - 258 WP_000288813.1 hypothetical protein Antitoxin
IUJ39_RS09020 (1809419) 1809419..1809624 - 206 Protein_1767 helix-turn-helix transcriptional regulator -
IUJ39_RS09025 (1809621) 1809621..1809836 - 216 Protein_1768 hypothetical protein -
IUJ39_RS09030 (1810131) 1810131..1810385 - 255 Protein_1769 transposase -
IUJ39_RS09035 (1810590) 1810590..1811813 - 1224 WP_140198188.1 RHS repeat-associated core domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1810062..1810385 323


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11779.61 Da        Isoelectric Point: 10.7239

>T180928 WP_000373725.1 NZ_CP064363:c1808813-1808481 [Salmonella enterica subsp. arizonae]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFAVSLDGAGTRTTGVIRCDQPRTI
DMGARNGKRLERLPDAVVNEVLARLEAILS

Download         Length: 333 bp

>T180928 NZ_CP085793:462196-462480 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGCAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9332.80 Da        Isoelectric Point: 4.3093

>AT180928 WP_000288813.1 NZ_CP064363:c1809071-1808814 [Salmonella enterica subsp. arizonae]
MYTTRLKKVGGSVMLAVPPAVLKTLALSTDSEVGMTIDNGCLIIEPRKRPCYSLEELLAQCDPNAEISEEDREWIDAPAV
GREIL

Download         Length: 258 bp

>AT180928 NZ_CP085793:461964-462206 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A741MVU5

Antitoxin

Source ID Structure
AlphaFold DB A0A741N4R3

References