Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1731520..1732174 Replicon chromosome
Accession NZ_CP064363
Organism Salmonella enterica subsp. arizonae strain PartD-Sarizonae-RM8376

Toxin (Protein)


Gene name cptA Uniprot ID A0A741MZF1
Locus tag IUJ39_RS08625 Protein ID WP_000250983.1
Coordinates 1731520..1731927 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A741MZI1
Locus tag IUJ39_RS08630 Protein ID WP_000354051.1
Coordinates 1731908..1732174 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ39_RS08605 (1727455) 1727455..1729188 - 1734 WP_140198176.1 single-stranded-DNA-specific exonuclease RecJ -
IUJ39_RS08610 (1729194) 1729194..1729907 - 714 WP_140198177.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IUJ39_RS08615 (1729931) 1729931..1730827 - 897 WP_000434304.1 site-specific tyrosine recombinase XerD -
IUJ39_RS08620 (1730940) 1730940..1731461 + 522 WP_058345970.1 flavodoxin FldB -
IUJ39_RS08625 (1731520) 1731520..1731927 - 408 WP_000250983.1 protein YgfX Toxin
IUJ39_RS08630 (1731908) 1731908..1732174 - 267 WP_000354051.1 FAD assembly factor SdhE Antitoxin
IUJ39_RS08635 (1732424) 1732424..1733404 + 981 WP_038397688.1 tRNA-modifying protein YgfZ -
IUJ39_RS08640 (1733506) 1733506..1734165 - 660 WP_000250284.1 hemolysin III family protein -
IUJ39_RS08645 (1734328) 1734328..1734639 - 312 WP_001182982.1 N(4)-acetylcytidine aminohydrolase -
IUJ39_RS08650 (1734797) 1734797..1736230 + 1434 WP_000737104.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16068.05 Da        Isoelectric Point: 11.1741

>T180927 WP_000250983.1 NZ_CP064363:c1731927-1731520 [Salmonella enterica subsp. arizonae]
VVQWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMMLLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRIMLQQPISR

Download         Length: 408 bp

>T180927 NZ_CP085793:355093-355584 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10496.00 Da        Isoelectric Point: 6.2227

>AT180927 WP_000354051.1 NZ_CP064363:c1732174-1731908 [Salmonella enterica subsp. arizonae]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDGEKRIFIRLLQNDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT180927 NZ_CP085793:354803-355096 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCTGCCCGTGCTGCCGCCGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A741MZF1

Antitoxin

Source ID Structure
AlphaFold DB A0A741MZI1

References