Detailed information of TA system TA180926

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeV-yfjZ/CbtA-CbeA
• Location: 1450711..1451430
• Replicon: chromosome
• Accession: NZ_CP064363
• Organism: Salmonella enterica subsp. arizonae strain PartD-Sarizonae-RM8376

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: IUJ39_RS07295
• Protein ID: WP_140198142.1
• Coordinates: 1451110..1451430 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: IUJ39_RS07290
• Protein ID: WP_140198141.1
• Coordinates: 1450711..1451076 (+)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IUJ39_RS07250 (1445846)	1445846..1446481	-	636	WP_140198133.1	inovirus Gp2 family protein	-
IUJ39_RS07255 (1447172)	1447172..1447495	+	324	WP_228550858.1	hypothetical protein	-
IUJ39_RS07260 (1447515)	1447515..1448318	+	804	WP_140198135.1	hypothetical protein	-
IUJ39_RS07265 (1448369)	1448369..1448548	+	180	WP_140198136.1	hypothetical protein	-
IUJ39_RS07270 (1448584)	1448584..1449012	+	429	WP_140198137.1	hypothetical protein	-
IUJ39_RS07275 (1449087)	1449087..1449908	+	822	WP_140198138.1	DUF932 domain-containing protein	-
IUJ39_RS07280 (1449979)	1449979..1450449	+	471	WP_140198139.1	DNA repair protein RadC	-
IUJ39_RS07285 (1450458)	1450458..1450679	+	222	WP_140198140.1	DUF987 domain-containing protein	-
IUJ39_RS07290 (1450711)	1450711..1451076	+	366	WP_140198141.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
IUJ39_RS07295 (1451110)	1451110..1451430	+	321	WP_140198142.1	TA system toxin CbtA family protein	Toxin
IUJ39_RS21760 (1452044)	1452044..1452907	-	864	WP_280527212.1	NEL-type E3 ubiquitin ligase domain-containing protein	-
IUJ39_RS21765 (1453742)	1453742..1454170	-	429	Protein_1432	E3 ubiquitin--protein ligase	-
IUJ39_RS07305 (1454309)	1454309..1455502	-	1194	Protein_1433	IS4 family transposase	-
IUJ39_RS07310 (1455516)	1455516..1456145	+	630	WP_228550859.1	DUF3289 family protein	-
IUJ39_RS07315 (1456180)	1456180..1456428	+	249	WP_140198144.1	DUF943 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (5-105)

Antitoxin

• Antitoxin CbeA (18-116)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12166.95 Da
• Isoelectric Point: 6.4855

>T180926 WP_140198142.1 NZ_CP064363:1451110-1451430 [Salmonella enterica subsp. arizonae]
MHISTVPATVPVSPRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDNSAIQEHIEAGITLADAVNFLMERYELVRIDRKGF
TWQEQTPFLTTIDLLRAKRATGLMHT

Nucleotide

• Length: 321 bp

>T180926 NZ_CP085793:45850-46161 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13483.21 Da
• Isoelectric Point: 5.9536

>AT180926 WP_140198141.1 NZ_CP064363:1450711-1451076 [Salmonella enterica subsp. arizonae]
MQSTTLSGSSAENASCLQWGIKRNITPCFGARLVQEGNHLYFLTDRSGFDGSFSDDEVLRLDQVFPLLMKQLERMLTTGE
LDPRCQHCVTLHHNGLTCEADTLGSHGYVYIAIYPQSAVTR

Nucleotide

• Length: 366 bp

>AT180926 NZ_CP085793:46162-46452 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA